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dc.rights.licenseopenen_US
dc.contributor.authorFARIA, Melissa
dc.contributor.authorGARCIA-REYERO, Natàlia
dc.contributor.authorPADRÓS, Francesc
dc.contributor.authorBABIN, Patrick J.
dc.contributor.authorSEBASTIÁN, David
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCACHOT, Jérôme
dc.contributor.authorPRATS, Eva
dc.contributor.authorARICK II, Mark
dc.contributor.authorII, Mark Arick
dc.contributor.authorRIAL, Eduardo
dc.contributor.authorKNOLL-GELLIDA, Anja
dc.contributor.authorMATHIEU, Guilaine
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLE BIHANIC, Florane
dc.contributor.authorLE BIHANIC, Florane
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorESCALON, B. Lynn
dc.contributor.authorZORZANO, Antonio
dc.contributor.authorSOARES, Amadeu M. V. M.
dc.contributor.authorRALDÚA, Demetrio
dc.date.accessioned2024-05-15T08:36:35Z
dc.date.available2024-05-15T08:36:35Z
dc.date.issued2015-10-22
dc.identifier.issn2045-2322en_US
dc.identifier.urioai:crossref.org:10.1038/srep15591
dc.identifier.uriorcid:0000-0001-7838-2027:10.1038/srep15591
dc.identifier.urioadoi:http://ria.ua.pt/bitstream/10773/16910/1/srep15591.pdf
dc.identifier.urioadoi:https://digital.csic.es/bitstream/10261/128178/1/srep_Rial%2c%20E._2015.pdf
dc.identifier.urioadoi:http://diposit.ub.edu/dspace/bitstream/2445/99680/1/658384.pdf
dc.identifier.urioadoi:http://europepmc.org/articles/pmc4614985?pdf=render
dc.identifier.urioai:researchgate.net:283122886
dc.identifier.uriftria:oai:ria.ua.pt:10773/16910
dc.identifier.urioadoi:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614985
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199859
dc.description.abstractEnAbstractTerrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceorcid
dc.sourceoadoi_repo
dc.sourceresearchgate
dc.sourcebase
dc.title.enZebrafish Models for Human Acute Organophosphorus Poisoning
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/srep15591en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalScientific Reportsen_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04575713
hal.version1
hal.date.transferred2024-05-15T08:36:38Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2015-10-22&rft.volume=5&rft.issue=1&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=FARIA,%20Melissa&GARCIA-REYERO,%20Nat%C3%A0lia&PADR%C3%93S,%20Francesc&BABIN,%20Patrick%20J.&SEBASTI%C3%81N,%20David&rft.genre=article


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