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A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorBOUDET-BERQUIER, Julie
hal.structure.identifierLaboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie [CHU Nîmes] [BESPIM]
dc.contributor.authorDEMATTEI, Christophe
hal.structure.identifierDirection santé environnement travail - Santé Publique France [DSET]
dc.contributor.authorGULDNER, Laurence
hal.structure.identifierSanté publique France, Cellule Régionale Pays de la Loire [Nantes, France]
dc.contributor.authorGALLAY, Anne
hal.structure.identifierMaladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
dc.contributor.authorMANOUVRIER, Sylvie
hal.structure.identifierEPI-PHARE [EPI-PHARE]
dc.contributor.authorBOTTON, Jérémie
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorPHILIPPAT, Claire
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
hal.structure.identifierDirection des alertes et des vigilances sanitaires [DAVS]
dc.contributor.authorBLOCH, Juliette
hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorSEMAILLE, Caroline
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
dc.contributor.authorODENT, Sylvie
hal.structure.identifierCEMC-Auvergne
dc.contributor.authorPERTHUS, Isabelle
hal.structure.identifierCentre Hospitalier Universitaire de La Réunion [CHU La Réunion]
dc.contributor.authorRANDRIANAIVO, Hanitra
hal.structure.identifierCentre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
hal.structure.identifierPathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies [URP 2496]
dc.contributor.authorBABAJKO, Sylvie
hal.structure.identifierCentre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
hal.structure.identifierSanté Ingénierie Biologie Saint-Etienne [SAINBIOSE]
dc.contributor.authorBARJAT, Tiphaine
hal.structure.identifierHôtel-Dieu de Nantes
dc.contributor.authorBENETEAU, Claire
hal.structure.identifierHôpitaux de Saint Maurice [HNSM]
dc.contributor.authorBRENNETOT, Naima
hal.structure.identifierLillebaelt Hospital [Kolding, Denmark] [LH]
dc.contributor.authorGARNE, Ester
hal.structure.identifierCentre Hospitalier Simone Veil [CH Simone Veil]
dc.contributor.authorHADDAD, Georges
hal.structure.identifierLaboratoire Modélisation, épidémiologie et surveillance des risques sanitaires [MESuRS]
dc.contributor.authorHOCINE, Mounia
hal.structure.identifierEquipe SPHERE (CERPOP)
dc.contributor.authorLACROIX, Isabelle
hal.structure.identifierService de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants [IRSN/PSE-SANTE/SESANE]
dc.contributor.authorLEURAUD, Klervi
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorMENCH, Michel
hal.structure.identifierSt George's, University of London
dc.contributor.authorMORRIS, Joan
hal.structure.identifierCHU Rouen
dc.contributor.authorPATRIER, Sophie
hal.structure.identifierUniversité de Liège
dc.contributor.authorSARTELET, Arnaud
hal.structure.identifierAP-HP Hôpital universitaire Robert-Debré [Paris]
dc.contributor.authorVERLOES, Alain
hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorBONALDI, Christophe
hal.structure.identifierDirection santé environnement travail - Santé Publique France [DSET]
dc.contributor.authorLE BARBIER, Mélina
hal.structure.identifierSanté publique France, Cellule Régionale Pays de la Loire [Nantes, France]
dc.contributor.authorGAGNIÈRE, Bertrand
hal.structure.identifierSanté publique France Provence-Alpes-Côte d'azur et Corse - Provence-Alps-French Riviera and Corsica [Marseille]
dc.contributor.authorPÉPIN, Philippe
hal.structure.identifierSanté publique France, Cellule Régionale Pays de la Loire [Nantes, France]
dc.contributor.authorOLLIVIER, Ronan
hal.structure.identifierSanté publique France, Cellule Régionale Pays de la Loire [Nantes, France]
dc.contributor.authorBITOUN, Monique
hal.structure.identifierSanté publique France, Cellule Régionale Pays de la Loire [Nantes, France]
dc.contributor.authorKING, Lisa
hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorGUAJARDO-VILLAR, Andrea
hal.structure.identifierDirection santé environnement travail - Santé Publique France [DSET]
dc.contributor.authorGOMES, Eugenia
hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorDESENCLOS, Jean-Claude
hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorREGNAULT, Nolwenn
hal.structure.identifierAP-HP - Hôpital Antoine Béclère [Clamart]
dc.contributor.authorBENACHI, Alexandra
dc.date2024-04-27
dc.date.issued2024-04-27
dc.identifier.issn0393-2990
dc.description.abstractEnIntroduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas. Methods: The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases’ homes concerning their plant product use. Results: After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed. Discussion: Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred
dc.language.isoen
dc.publisherSpringer Verlag
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enBirth defects
dc.subject.enCluster
dc.subject.enCongenital anomalies
dc.subject.enEnvironment
dc.subject.enLimb reduction defects
dc.subject.enSpatiotemporal analyses
dc.title.enA multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France
dc.typeArticle de revue
dc.identifier.doi10.1007/s10654-024-01125-5
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalEuropean Journal of Epidemiology
bordeaux.peerReviewedoui
hal.identifieranses-04573454
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//anses-04573454v1
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