A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France
BOUDET-BERQUIER, Julie
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
DEMATTEI, Christophe
Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie [CHU Nîmes] [BESPIM]
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Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie [CHU Nîmes] [BESPIM]
BOUDET-BERQUIER, Julie
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
DEMATTEI, Christophe
Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie [CHU Nîmes] [BESPIM]
Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique Innovation et Méthodologie [CHU Nîmes] [BESPIM]
MANOUVRIER, Sylvie
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
PHILIPPAT, Claire
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
SEMAILLE, Caroline
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
ODENT, Sylvie
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
BABAJKO, Sylvie
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies [URP 2496]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies [URP 2496]
BARJAT, Tiphaine
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Santé Ingénierie Biologie Saint-Etienne [SAINBIOSE]
HOCINE, Mounia
Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires [MESuRS]
Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires [MESuRS]
LEURAUD, Klervi
Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants [IRSN/PSE-SANTE/SESANE]
Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants [IRSN/PSE-SANTE/SESANE]
BONALDI, Christophe
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
PÉPIN, Philippe
Santé publique France Provence-Alpes-Côte d'azur et Corse - Provence-Alps-French Riviera and Corsica [Marseille]
Santé publique France Provence-Alpes-Côte d'azur et Corse - Provence-Alps-French Riviera and Corsica [Marseille]
GUAJARDO-VILLAR, Andrea
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
DESENCLOS, Jean-Claude
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
REGNAULT, Nolwenn
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
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Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Langue
en
Article de revue
Ce document a été publié dans
European Journal of Epidemiology. 2024-04-27
Springer Verlag
Date de soutenance
2024-04-27Résumé en anglais
Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where ...Lire la suite >
Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas. Methods: The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases’ homes concerning their plant product use. Results: After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed. Discussion: Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred< Réduire
Mots clés en anglais
Birth defects
Cluster
Congenital anomalies
Environment
Limb reduction defects
Spatiotemporal analyses
Origine
Importé de hal