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Impact of Preformed Donor-Specific Anti-HLA-Cw and Anti-HLA-DP Antibodies on Acute Antibody-Mediated Rejection in Kidney Transplantation

dc.rights.licenseopenen_US
dc.contributor.authorLABOUX, Timothee
dc.contributor.authorLENAIN, Remi
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorVISENTIN, Jonathan
dc.contributor.authorFLAHAUT, Gauthier
dc.contributor.authorCHAMLEY, Paul
dc.contributor.authorPROVÔT, François
dc.contributor.authorTOP, Isabelle
dc.contributor.authorKERLEAU, Clarisse
dc.contributor.authorLABALETTE, Myriam
dc.contributor.authorCHOUKROUN, Gabriel
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
dc.contributor.authorBLANCHO, Gilles
dc.contributor.authorHAZZAN, Marc
dc.contributor.authorMAANAOUI, Mehdi
dc.date.accessioned2024-05-14T13:01:20Z
dc.date.available2024-05-14T13:01:20Z
dc.date.issued2023-11
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199823
dc.description.abstractEnGiven the risk of rejection, the presence of preformed donor specific antibodies (DSA) contraindicates transplantation in most allocation systems. However, HLA-Cw and -DP DSA escape this censorship. We performed a multicentric observational study, in which the objective was to determinate risk factors of acute antibody-mediated rejection (aABMR) in recipients transplanted with preformed isolated Cw- or DP-DSA. Between 2010 and 2019, 183 patients were transplanted with a preformed isolated Cw- or DP-DSA (92 Cw-DSA; 91 DP-DSA). At 2 years, the incidence of aABMR was 12% in the Cw-DSA group, versus 28% in the DP-DSA group. Using multivariable Cox regression model, the presence of a preformed DP-DSA was associated with an increased risk of aABMR (HR = 2.32 [1.21–4.45 (p = 0.001)]) compared with Cw-DSA. We also observed a significant association between the DSA’s MFI on the day of transplant and the risk of aABMR (HR = 1.09 [1.08–1.18], p = 0.032), whatever the DSA was. Interaction term analysis found an increased risk of aABMR in the DP-DSA group compared with Cw-DSA, but only for MFI below 3,000. These results may plead for taking these antibodies into account in the allocation algorithms, in the same way as other DSA. Copyright © 2023 Laboux, Lenain, Visentin, Flahaut, Chamley, Provôt, Top, Kerleau, Labalette, Choukroun, Couzi, Blancho, Hazzan and Maanaoui.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enDonor-specific antibodies
dc.subject.enkidney transplant
dc.subject.enacute antibody-mediated rejection
dc.subject.enHLA-Cw
dc.subject.enHLA-DP
dc.title.enImpact of Preformed Donor-Specific Anti-HLA-Cw and Anti-HLA-DP Antibodies on Acute Antibody-Mediated Rejection in Kidney Transplantation
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/ti.2023.11416en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
bordeaux.journalTransplant Internationalen_US
bordeaux.page11416en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplant%20International&rft.date=2023-11&rft.volume=36&rft.spage=11416&rft.epage=11416&rft.au=LABOUX,%20Timothee&LENAIN,%20Remi&VISENTIN,%20Jonathan&FLAHAUT,%20Gauthier&CHAMLEY,%20Paul&rft.genre=article


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