Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study
dc.rights.license | open | en_US |
dc.contributor.author | TAN, Byorn W L | |
dc.contributor.author | TAN, Bryce W Q | |
dc.contributor.author | TAN, Amelia L M | |
dc.contributor.author | SCHRIVER, Emily R | |
dc.contributor.author | GUTIERREZ-SACRISTAN, Alba | |
dc.contributor.author | DAS, Priyam | |
dc.contributor.author | YUAN, William | |
dc.contributor.author | HUTCH, Meghan R | |
dc.contributor.author | GARCIA BARRIO, Noelia | |
dc.contributor.author | PEDRERA JIMENEZ, Miguel | |
dc.contributor.author | ABU-EL-RUB, Noor | |
dc.contributor.author | MORRIS, Michele | |
dc.contributor.author | MOAL, Bertrand | |
dc.contributor.author | VERDY, Guillaume | |
dc.contributor.author | CHO, Kelly | |
dc.contributor.author | HO, Yuk-Lam | |
dc.contributor.author | PATEL, Lav P | |
dc.contributor.author | DAGLIATI, Arianna | |
dc.contributor.author | NEURAZ, Antoine | |
dc.contributor.author | KLANN, Jeffrey G | |
dc.contributor.author | SOUTH, Andrew M | |
dc.contributor.author | VISWESWARAN, Shyam | |
dc.contributor.author | HANAUER, David A | |
dc.contributor.author | MAIDLOW, Sarah E | |
dc.contributor.author | LIU, Mei | |
dc.contributor.author | MOWERY, Danielle L | |
dc.contributor.author | BATUGO, Ashley | |
dc.contributor.author | MAKOUDJOU, Adeline | |
dc.contributor.author | TIPPMANN, Patric | |
dc.contributor.author | ZOLLER, Daniela | |
dc.contributor.author | BRAT, Gabriel A | |
dc.contributor.author | LUO, Yuan | |
dc.contributor.author | AVILLACH, Paul | |
dc.contributor.author | BELLAZZI, Riccardo | |
dc.contributor.author | CHIOVATO, Luca | |
dc.contributor.author | MALOVINI, Alberto | |
dc.contributor.author | TIBOLLO, Valentina | |
dc.contributor.author | SAMAYAMUTHU, Malarkodi Jebathilagam | |
dc.contributor.author | SERRANO BALAZOTE, Pablo | |
dc.contributor.author | XIA, Zongqi | |
dc.contributor.author | LOH, Ne Hooi Will | |
dc.contributor.author | CHIUDINELLI, Lorenzo | |
dc.contributor.author | BONZEL, Clara-Lea | |
dc.contributor.author | HONG, Chuan | |
dc.contributor.author | ZHANG, Harrison G | |
dc.contributor.author | WEBER, Griffin M | |
dc.contributor.author | KOHANE, Isaac S | |
dc.contributor.author | CAI, Tianxi | |
dc.contributor.author | OMENN, Gilbert S | |
dc.contributor.author | HOLMES, John H | |
dc.contributor.author | NGIAM, Kee Yuan | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GRIFFIER, Romain | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | JOUHET, Vianney | |
dc.date.accessioned | 2024-05-14T07:19:57Z | |
dc.date.available | 2024-05-14T07:19:57Z | |
dc.date.issued | 2023-01-01 | |
dc.identifier.issn | 2589-5370 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199810 | |
dc.description.abstractEn | BACKGROUND: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. METHODS: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1-365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. FINDINGS: Advanced age (HR 2.77, 95%CI 2.53-3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03-4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55-5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14-1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37-0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17-1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20-1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45-1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80-13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10-1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32-1.67) and 365 days (RR 1.54, 95%CI 1.21-1.96) compared to COVID-19 patients with no AKI. INTERPRETATION: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. FUNDING: Authors are supported by various funders, with full details stated in the acknowledgement section. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject.en | Acute kidney injury | |
dc.subject.en | COVID-19 | |
dc.subject.en | Chronic kidney disease | |
dc.subject.en | Electronic health records | |
dc.subject.en | SARS-CoV-2 | |
dc.title.en | Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study | |
dc.title.alternative | EClinicalMedicine | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.eclinm.2022.101724 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 36381999 | en_US |
bordeaux.journal | EClinicalMedicine | en_US |
bordeaux.page | 101724 | en_US |
bordeaux.volume | 55 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | AHEAD_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | National Institutes of Health | en_US |
hal.identifier | hal-04574714 | |
hal.version | 1 | |
hal.date.transferred | 2024-05-14T12:00:07Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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