Addressing unmeasured confounders in cohort studies: Instrumental variable method for a time-fixed exposure on an outcome trajectory
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE BOURDONNEC, Kateline | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TZOURIO, Christophe
IDREF: 69829209 | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | MURA, Thibault | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MISHRA, Aniket | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TREGOUET, David-Alexandre | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X IDREF: 114375747 | |
| dc.date.accessioned | 2024-05-13T07:21:01Z | |
| dc.date.available | 2024-05-13T07:21:01Z | |
| dc.date.issued | 2023-12-14 | |
| dc.identifier.issn | 1521-4036 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199765 | |
| dc.description.abstractEn | Instrumental variable methods, which handle unmeasured confounding by targeting the part of the exposure explained by an exogenous variable not subject to confounding, have gained much interest in observational studies. We consider the very frequent setting of estimating the unconfounded effect of an exposure measured at baseline on the subsequent trajectory of an outcome repeatedly measured over time. We didactically explain how to apply the instrumental variable method in such setting by adapting the two-stage classical methodology with (1) the prediction of the exposure according to the instrumental variable, (2) its inclusion into a mixed model to quantify the exposure association with the subsequent outcome trajectory, and (3) the computation of the estimated total variance. A simulation study illustrates the consequences of unmeasured confounding in classical analyses and the usefulness of the instrumental variable approach. The methodology is then applied to 6224 participants of the 3C cohort to estimate the association of type-2 diabetes with subsequent cognitive trajectory, using 42 genetic polymorphisms as instrumental variables. This contribution shows how to handle endogeneity when interested in repeated outcomes, along with a R implementation. However, it should still be used with caution as it relies on instrumental variable assumptions hardly testable in practice. | |
| dc.description.sponsorship | Modèles Dynamiques pour les Etudes Epidémiologiques Longitudinales sur les Maladies Chroniques - ANR-18-CE36-0004 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Causality | |
| dc.subject.en | Cohort Study | |
| dc.subject.en | Instrumental Variable | |
| dc.subject.en | Mixed Model | |
| dc.subject.en | Repeated Data | |
| dc.title.en | Addressing unmeasured confounders in cohort studies: Instrumental variable method for a time-fixed exposure on an outcome trajectory | |
| dc.title.alternative | Biom J | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/bimj.202200358 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38098309 | en_US |
| bordeaux.journal | Biometrical Journal | en_US |
| bordeaux.page | e2200358 | en_US |
| bordeaux.volume | 66 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | ELEANOR_BPH | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.team | HEALTHY_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biometrical%20Journal&rft.date=2023-12-14&rft.volume=66&rft.issue=1&rft.spage=e2200358&rft.epage=e2200358&rft.eissn=1521-4036&rft.issn=1521-4036&rft.au=LE%20BOURDONNEC,%20Kateline&SAMIERI,%20Cecilia&TZOURIO,%20Christophe&MURA,%20Thibault&MISHRA,%20Aniket&rft.genre=article |
