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dc.rights.licenseopenen_US
dc.contributor.authorPASTOR, Yadira
dc.contributor.authorREYNARD, Olivier
dc.contributor.authorIAMPIETRO, Mathieu
dc.contributor.authorSURENAUD, Mathieu
dc.contributor.authorPICARD, Florence
dc.contributor.authorEL JAHRANI, Nora
dc.contributor.authorLEFEBVRE, Cecile
dc.contributor.authorHAMMOUDI, Adele
dc.contributor.authorDUPATY, Lea
dc.contributor.authorBRISEBARD, Elise
dc.contributor.authorREYNARD, Stephanie
dc.contributor.authorMOUREAUX, Elodie
dc.contributor.authorMOROSO, Marie
dc.contributor.authorDURAND, Stephanie
dc.contributor.authorGONZALEZ, Claudia
dc.contributor.authorAMURRI, Lucia
dc.contributor.authorGALLOUET, Anne-Sophie
dc.contributor.authorMARLIN, Romain
dc.contributor.authorBAIZE, Sylvain
dc.contributor.authorCHEVILLARD, Eve
dc.contributor.authorRAOUL, Herve
dc.contributor.authorHOCINI, Hakim
dc.contributor.authorCENTLIVRE, Mireille
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorHORVAT, Branka
dc.contributor.authorGODOT, Veronique
dc.contributor.authorLEVY, Yves
dc.contributor.authorCARDINAUD, Sylvain
dc.date.accessioned2024-05-06T14:58:21Z
dc.date.available2024-05-06T14:58:21Z
dc.date.issued2024-03-19
dc.identifier.issn2666-3791en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199674
dc.description.abstractEnNipah virus (NiV) has been recently ranked by the World Health Organization as being among the top eight emerging pathogens likely to cause major epidemics, whereas no therapeutics or vaccines have yet been approved. We report a method to deliver immunogenic epitopes from NiV through the targeting of the CD40 receptor of antigen-presenting cells by fusing a selected humanized anti-CD40 monoclonal antibody to the Nipah glycoprotein with conserved NiV fusion and nucleocapsid peptides. In the African green monkey model, CD40.NiV induces specific immunoglobulin A (IgA) and IgG as well as cross-neutralizing responses against circulating NiV strains and Hendra virus and T cell responses. Challenge experiments using a NiV-B strain demonstrate the high protective efficacy of the vaccine, with all vaccinated animals surviving and showing no significant clinical signs or virus replication, suggesting that the CD40.NiV vaccine conferred sterilizing immunity. Overall, results obtained with the CD40.NiV vaccine are highly promising in terms of the breadth and efficacy against NiV.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Instituteen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enCD40-targeting vaccine
dc.subject.enHenipavirus
dc.subject.enNipah virus
dc.subject.encross-neutralizing responses
dc.subject.enDendritic cell-based vaccine
dc.subject.enEpitope mapping
dc.subject.enGerminal center reaction
dc.subject.enNeutralizing antibodies
dc.subject.enProphylactic vaccine
dc.subject.enSterilizing immunity
dc.title.enA vaccine targeting antigen-presenting cells through CD40 induces protective immunity against Nipah disease
dc.title.alternativeCell Rep Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.xcrm.2024.101467en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38471503en_US
bordeaux.journalCell Reports Medicineen_US
bordeaux.page101467en_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04569963
hal.version1
hal.date.transferred2024-05-06T14:58:25Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports%20Medicine&rft.date=2024-03-19&rft.volume=5&rft.issue=3&rft.spage=101467&rft.epage=101467&rft.eissn=2666-3791&rft.issn=2666-3791&rft.au=PASTOR,%20Yadira&REYNARD,%20Olivier&IAMPIETRO,%20Mathieu&SURENAUD,%20Mathieu&PICARD,%20Florence&rft.genre=article


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