Prefrontal circuits encode both general danger and specific threat representations
dc.rights.license | open | en_US |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MARTIN-FERNANDEZ, Mario | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MENEGOLLA, Ana Paula | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | LOPEZ-FERNANDEZ, Guillem | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | WINKE, Nanci | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | JERCOG, Daniel | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | KIM, Ha-Rang | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | GIRARD, Delphine | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | DEJEAN, Cyril | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | HERRY, Cyril | |
dc.date.accessioned | 2024-05-06T09:59:21Z | |
dc.date.available | 2024-05-06T09:59:21Z | |
dc.date.issued | 2023-12 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199649 | |
dc.description.abstractEn | Behavioral adaptation to potential threats requires both a global representation of danger to prepare the organism to react in a timely manner but also the identification of specific threatening situations to select the appropriate behavioral responses. The prefrontal cortex is known to control threat-related behaviors, yet it is unknown whether it encodes global defensive states and/or the identity of specific threatening encounters. Using a new behavioral paradigm that exposes mice to different threatening situations, we show that the dorsomedial prefrontal cortex (dmPFC) encodes a general representation of danger while simultaneously encoding a specific neuronal representation of each threat. Importantly, the global representation of danger persisted in error trials that instead lacked specific threat identity representations. Consistently, optogenetic prefrontal inhibition impaired overall behavioral performance and discrimination of different threatening situations without any bias toward active or passive behaviors. Together, these data indicate that the prefrontal cortex encodes both a global representation of danger and specific representations of threat identity to control the selection of defensive behaviors. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc. | |
dc.description.sponsorship | Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008 | en_US |
dc.language.iso | EN | en_US |
dc.subject.en | Animals | |
dc.subject.en | Mice | |
dc.subject.en | Neurons* / physiology | |
dc.subject.en | Optogenetics | |
dc.subject.en | Prefrontal Cortex* / physiology | |
dc.title.en | Prefrontal circuits encode both general danger and specific threat representations | |
dc.title.alternative | Nat Neurosci | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41593-023-01472-8 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 37904042 | en_US |
bordeaux.journal | Nature Neuroscience | en_US |
bordeaux.page | 2147-2157 | en_US |
bordeaux.volume | 26 | en_US |
bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
bordeaux.issue | 12 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | Circuits neuronaux des apprentissages associatifs | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-04569370 | |
hal.version | 1 | |
hal.date.transferred | 2024-05-06T09:59:23Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Neuroscience&rft.date=2023-12&rft.volume=26&rft.issue=12&rft.spage=2147-2157&rft.epage=2147-2157&rft.au=MARTIN-FERNANDEZ,%20Mario&MENEGOLLA,%20Ana%20Paula&LOPEZ-FERNANDEZ,%20Guillem&WINKE,%20Nanci&JERCOG,%20Daniel&rft.genre=article |
Fichier(s) constituant ce document
Fichiers | Taille | Format | Vue |
---|---|---|---|
Il n'y a pas de fichiers associés à ce document. |