Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents
| dc.rights.license | open | en_US |
| hal.structure.identifier | Venins et Activités Biologiques [VAcBio] | |
| dc.contributor.author | BONNAFÉ, Elsa | |
| hal.structure.identifier | Laboratoire d'Ecologie Alpine [LECA] | |
| dc.contributor.author | SRODA, Sophie | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | BUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154 IDREF: 070478090 | |
| hal.structure.identifier | Institut national universitaire Champollion [Albi] [INUC] | |
| dc.contributor.author | VALIÈRE, Amélie | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | PEDELLUC, Julie | |
| hal.structure.identifier | Venins et Activités Biologiques [VAcBio] | |
| dc.contributor.author | MARTY, Pierre | |
| hal.structure.identifier | Géographie de l'environnement [GEODE] | |
| hal.structure.identifier | Institut national universitaire Champollion [Albi] [INUC] | |
| dc.contributor.author | GERET, Florence | |
| dc.date.accessioned | 2024-05-06T09:28:01Z | |
| dc.date.available | 2024-05-06T09:28:01Z | |
| dc.date.issued | 2015-07 | |
| dc.identifier.issn | 0944-1344 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199643 | |
| dc.description.abstractEn | Pharmaceutical products are a major group of chemical compounds that are continuously released into the environment. The primary pathway of pharmaceuticals to the aquatic environment is the discharge of wastewater effluents. The Psychiatric hospital of Montpon (Dordogne, France) operates with its wastewater treatment plant. We first evaluated the presence and concentrations of 27 pharmaceuticals compounds in these effluents. All of the 27 compounds were detected in these wastewater effluents at concentrations ranging between 37,500 ng L−1 (paracetamol) and 150 ng L−1 (citalopram). The aim of the study was then to evaluate the exposure effects of the effluents on cytochrome P450, GST, and MXR responses in Corbicula fluminea gills and digestive glands. Experiments on clams exposed during 1, 3, 7 14, and 21 days revealed a strong and continuous overexpression of mdr1 (multidrug resistant 1) gene expression in gills and transitory variations in pi-gst expression and GST activity. EROD activity increased also transitory after 1 day in the digestive gland of exposed clams. These results indicated that in the effluent, some molecules have undergone metabolism of phase 1 and/or phase 2. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Hospital wastewater effluents | |
| dc.subject.en | Psychotropics | |
| dc.subject.en | Freshwater molluscs | |
| dc.subject.en | Corbicula fluminea | |
| dc.subject.en | Cytochrome P450 | |
| dc.subject.en | GST | |
| dc.subject.en | MXR | |
| dc.title.en | Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s11356-015-4309-x | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie du développement/Embryologie et organogenèse | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie animale/Zoologie des invertébrés | en_US |
| bordeaux.journal | Environmental Science and Pollution Research | en_US |
| bordeaux.page | 11033-11046 | en_US |
| bordeaux.volume | 22 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.issue | 14 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | LPTC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-02419293 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Pollution%20Research&rft.date=2015-07&rft.volume=22&rft.issue=14&rft.spage=11033-11046&rft.epage=11033-11046&rft.eissn=0944-1344&rft.issn=0944-1344&rft.au=BONNAF%C3%89,%20Elsa&SRODA,%20Sophie&BUDZINSKI,%20H%C3%A9l%C3%A8ne&VALI%C3%88RE,%20Am%C3%A9lie&PEDELLUC,%20Julie&rft.genre=article |
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