Factors associated with COVID-19 severity in patients with spondyloarthritis: Results of the French RMD COVID-19 cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | PERROT, L. | |
| dc.contributor.author | BOYER, L. | |
| dc.contributor.author | FLIPO, R.-M. | |
| dc.contributor.author | MAROTTE, H. | |
| dc.contributor.author | PERTUISET, E. | |
| dc.contributor.author | MICELI, C. | |
| dc.contributor.author | THOMAS, T. | |
| dc.contributor.author | SEROR, R. | |
| dc.contributor.author | CHAZERAIN, P. | |
| dc.contributor.author | ROUX, N. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | RICHEZ, Christophe | |
| dc.contributor.author | PHAM, T. | |
| dc.contributor.author | CONSORTIUM, FAI2R/SFR/SNFMI/SOFREMIP/CRI/IMIDIATE | |
| dc.date.accessioned | 2024-05-03T09:40:51Z | |
| dc.date.available | 2024-05-03T09:40:51Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 1297-319X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199604 | |
| dc.description.abstractEn | Objectives: The objective of the current study was to evaluate the severity of COVID-19 and identify factors associated with severe disease outcomes in patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic and musculoskeletal disease (RMD). Methods: We utilized patient data from the French national multicenter RMD COVID-19 cohort (NCT04353609). The primary outcome was to describe COVID-19 characteristics in patients with SpA based on disease severity of COVID-19 (mild, moderate or severe) with serious infection including moderate and severe cases. The secondary outcome was to identify the factors associated with serious COVID-19 classification. Results: Among the 626 patients with SpA (56% female, mean age 49 ± 14 years) from the French RMD cohort, COVID-19 severity was mild in 508 (81%), moderate in 93 (15%), and severe in 25 (4%) patients. Clinical signs and symptoms of COVID-19 were reported in 587 (94%) patients, with the most frequent presented symptom of fever (63%) and cough (62%), followed by flu-like symptoms (53%), agueusia (39%), anosmia (37%), dyspnea (32%) and diarrhea (19.9%). COVID-19 severity was associated with corticosteroid therapy (OR = 3.08 [95% CI: 1.44–6.58], P = 0.004) and age (OR = 1.06 [95% CI: 1.04–1.08], P < 0.001) while use of tumor necrosis factor inhibitor (TNFi, OR = 0.27 [95% CI: 0.09–0.78], P = 0.01) was associated with less severe disease. We did not identify an association between NSAID use and COVID-19 severity. Conclusions: In this study, the majority of patients with SpA had a favorable COVID-19 outcome. We confirmed age and corticosteroids therapy had a negative impact on disease outcomes while TNFi use was protective. © 2023 Société française de rhumatologie | |
| dc.language.iso | EN | en_US |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Rheumatic musculoskeletal diseases | |
| dc.subject.en | Spondyloarthritis | |
| dc.subject.en | Psoriatic arthritis | |
| dc.title.en | Factors associated with COVID-19 severity in patients with spondyloarthritis: Results of the French RMD COVID-19 cohort | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jbspin.2023.105608 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 37414137 | en_US |
| bordeaux.journal | Joint Bone Spine | en_US |
| bordeaux.volume | 90 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
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| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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