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Resective epilepsy surgery and its impact on depression in adults: a systematic review, meta-analysis, and implications for future research

dc.rights.licenseopenen_US
dc.contributor.authorHERNANDEZ POBLETE, Natalia
dc.contributor.authorGAY, Florian
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSALVO, Francesco
IDREF: 221043470
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorMICOULAUD FRANCHI, Jean Arthur
IDREF: 199759170
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBIENVENU, Thomas
dc.contributor.authorCOELHO, Julien
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorAUPY, Jerome
dc.date.accessioned2024-05-03T09:27:13Z
dc.date.available2024-05-03T09:27:13Z
dc.date.issued2024-03-05
dc.identifier.issn0022-3050en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199601
dc.description.abstractEnBACKGROUND: How epilepsy surgery influences the bidirectional relationship of epilepsy and depression remains poorly defined. METHOD: For a better understanding of this question, we conducted a systematic review and meta-analysis of risk ratio on depression prevalence before and after epilepsy surgery, using Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Three databases were comprehensively screened for all studies assessing depression before and after resective surgery in adult epileptic patients until 8 October 2022. Studies were included if depression was assessed before and after epilepsy surgery regardless of the time of follow-up. A total of 1917 studies were screened for eligibility and 91 full-texts up for inclusion; 35 studies were finally included, 25 studies and 2563 patients were included in main meta-analysis and 10 for exploratory analysis. Risk of bias was assessed using Risk Of Bias In Non-randomised Studies - of Interventions (ROBINS-I) from Cochrane. To derive the pooled depression rates before and after surgery, a meta-analysis with inversed-variance was performed using random-effects logistic models with Peto's correction and a 95% CI. Heterogeneity was assessed with Cochran's Q-test along with its derived measure of inconsistency I(2). RESULTS: Overall, the depression rates before and after resective epilepsy surgery were 0.70 (0.53 to 0.91) 95% CI, suggesting that the rate of depression at last follow-up evaluation tends to decrease after Resective Epilepsy Surgery (RES). Subgroup analysis suggest a positive long-term effect appears with a significant lower rates of depression already 6 months (0.61 (0.38 to 0.98)), after surgery which is maintained over time after 1 year (0.53 (0.31 to 0.90)), and after 2 years (0.62 (0.42 to 0.92)). CONCLUSION: This important finding should be taken in consideration before resective surgery for drug-resistant epilepsies. However, prospective studies should be conducted to characterise which patient, at the individual level, might be at risk of de novo or worsening of depression. PROSPERO REGISTRATION NUMBER: CRD42022355386.
dc.language.isoENen_US
dc.title.enResective epilepsy surgery and its impact on depression in adults: a systematic review, meta-analysis, and implications for future research
dc.title.alternativeJ Neurol Neurosurg Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/jnnp-2023-333073en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38443157en_US
bordeaux.journalJournal of Neurology, Neurosurgery and Psychiatryen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04567383
hal.version1
hal.date.transferred2024-05-03T09:27:14Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Neurology,%20Neurosurgery%20and%20Psychiatry&rft.date=2024-03-05&rft.eissn=0022-3050&rft.issn=0022-3050&rft.au=HERNANDEZ%20POBLETE,%20Natalia&GAY,%20Florian&SALVO,%20Francesco&MICOULAUD%20FRANCHI,%20Jean%20Arthur&BIENVENU,%20Thomas&rft.genre=article


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