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Multimodal nanogels combining ZW800-1 as an optical absorber and gadolinium chelates for multispectral optoacoustic tomography (MSOT) and magnetic resonance imaging (MRI)

dc.rights.licenseopenen_US
dc.contributor.authorGOSEE, Camille
dc.contributor.authorMOREAU, Juliette
dc.contributor.authorCADIOU, Cyril
dc.contributor.authorCALLEWAERT, Maite
dc.contributor.authorHENOUMONT, Celine
dc.contributor.authorLARBANOIX, Lionel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMOLINARI, Michael
dc.contributor.authorVOICU, Sorina
dc.contributor.authorPORTEFAIX, Christophe
dc.contributor.authorLAURENT, Sophie
dc.contributor.authorCHUBURU, Francoise
dc.date.accessioned2024-05-02T07:46:31Z
dc.date.available2024-05-02T07:46:31Z
dc.date.issued2023
dc.identifier.issn2052-1553en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199561
dc.description.abstractEnThe challenge of imaging is to combine resolution and sensitivity in order to gain accuracy in diagnosis. No single modality can provide comprehensive information. Then, the solution is to design probes that are able to gather on a single platform the best features of the different imaging modalities. To achieve this objective, we have combined two types of probes, one associated with photoacoustic imaging (PAI) and the other with magnetic resonance imaging (MRI), within polysaccharide-based nanohydrogels. For that, chitosan (CS) which is a cationic polysaccharide was grafted with the photoacoustic probe ZW800-1. The synthesis of the corresponding CS-ZW800 and the purification conditions that allow to overcome ZW800 aggregation on the course of the protocol were carefully analyzed. Nanohydrogels that encapsulated gadolinium chelates as MRI probes were further obtained by ionic gelation between CS-ZW800 and the anionic hyaluronic acid (HA) in the presence of tripolyphosphate (TPP) as an ionogenic cross-linker. The bimodal nanohydrogels were then subjected to MSOT and MRI experiments. Upon excitation at 770 nm the nanoparticles were then able to produce a significant MSOT signal while in MRI at 3T, a significant positive contrast was obtained with low Gd doses.
dc.language.isoENen_US
dc.title.enMultimodal nanogels combining ZW800-1 as an optical absorber and gadolinium chelates for multispectral optoacoustic tomography (MSOT) and magnetic resonance imaging (MRI)
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/D3QI01167Den_US
dc.subject.halChimieen_US
bordeaux.journalInorganic Chemistry Frontiersen_US
bordeaux.page6357-6368en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue21en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04444869
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Inorganic%20Chemistry%20Frontiers&rft.date=2023&rft.volume=10&rft.issue=21&rft.spage=6357-6368&rft.epage=6357-6368&rft.eissn=2052-1553&rft.issn=2052-1553&rft.au=GOSEE,%20Camille&MOREAU,%20Juliette&CADIOU,%20Cyril&CALLEWAERT,%20Maite&HENOUMONT,%20Celine&rft.genre=article


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