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Causal relationships between risk of venous thromboembolism and 18 cancers: a bidirectional Mendelian randomization analysis

dc.rights.licenseopenen_US
dc.contributor.authorCORNISH, Naomi
dc.contributor.authorHAYCOCK, Philip
dc.contributor.authorBRENNER, Hermann
dc.contributor.authorFIGUEIREDO, Jane C
dc.contributor.authorGALESLOOT, Tessel E
dc.contributor.authorGRANT, Robert C
dc.contributor.authorJOHANSSON, Mattias
dc.contributor.authorMARIOSA, Daniela
dc.contributor.authorMCKAY, James
dc.contributor.authorPAI, Rish
dc.contributor.authorPELLATT, Andrew J
dc.contributor.authorSAMADDER, N Jewel
dc.contributor.authorSHI, Jianxin
dc.contributor.authorTHIBORD, Florian
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorVOEGELE, Catherine
dc.contributor.authorTHIRLWELL, Chrissie
dc.contributor.authorMUMFORD, Andrew
dc.contributor.authorLANGDON, Ryan
dc.contributor.authorINTERLYMPH CONSORTIUM, Invent- M. V. P. Consortium
dc.date.accessioned2024-04-30T15:37:59Z
dc.date.available2024-04-30T15:37:59Z
dc.date.issued2024-02-01
dc.identifier.issn1464-3685en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199554
dc.description.abstractEnBACKGROUND: People with cancer experience high rates of venous thromboembolism (VTE). Risk of subsequent cancer is also increased in people experiencing their first VTE. The causal mechanisms underlying this association are not completely understood, and it is unknown whether VTE is itself a risk factor for cancer. METHODS: We used data from large genome-wide association study meta-analyses to perform bidirectional Mendelian randomization analyses to estimate causal associations between genetic liability to VTE and risk of 18 different cancers. RESULTS: We found no conclusive evidence that genetic liability to VTE was causally associated with an increased incidence of cancer, or vice versa. We observed an association between liability to VTE and pancreatic cancer risk [odds ratio for pancreatic cancer: 1.23 (95% confidence interval: 1.08-1.40) per log-odds increase in VTE risk, P = 0.002]. However, sensitivity analyses revealed this association was predominantly driven by a variant proxying non-O blood group, with inadequate evidence to suggest a causal relationship. CONCLUSIONS: These findings do not support the hypothesis that genetic liability to VTE is a cause of cancer. Existing observational epidemiological associations between VTE and cancer are therefore more likely to be driven by pathophysiological changes which occur in the setting of active cancer and anti-cancer treatments. Further work is required to explore and synthesize evidence for these mechanisms.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMendelian randomization
dc.subject.enDeep vein thrombosis
dc.subject.enGenetic epidemiology
dc.subject.enMalignancy
dc.subject.enPulmonary embolus
dc.title.enCausal relationships between risk of venous thromboembolism and 18 cancers: a bidirectional Mendelian randomization analysis
dc.title.alternativeInt J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ije/dyad170en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38124529en_US
bordeaux.journalInternational Journal of Epidemiologyen_US
bordeaux.pagedyad170en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04564673
hal.version1
hal.date.transferred2024-04-30T15:38:03Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Epidemiology&rft.date=2024-02-01&rft.volume=53&rft.issue=1&rft.spage=dyad170&rft.epage=dyad170&rft.eissn=1464-3685&rft.issn=1464-3685&rft.au=CORNISH,%20Naomi&HAYCOCK,%20Philip&BRENNER,%20Hermann&FIGUEIREDO,%20Jane%20C&GALESLOOT,%20Tessel%20E&rft.genre=article


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