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Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax
dc.rights.license | open | en_US |
hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
dc.contributor.author | SIMONYAN, Lilit | |
hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
dc.contributor.author | GONIN, Mathilde | |
dc.contributor.author | HANKS, James | |
dc.contributor.author | FRIEDLEIN, Jordan | |
hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
dc.contributor.author | DUTREC, Kevin | |
hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
dc.contributor.author | AROKIUM, Hubert | |
hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
dc.contributor.author | ROUCHIDANE EYITAYO, Akande | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | DOUDY, Toukounou Megann | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | CHAIGNEPAIN, Stephane | |
hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
dc.contributor.author | MANON, Stephen | |
dc.contributor.author | DEJEAN, Laurent | |
dc.date.accessioned | 2024-04-30T12:48:44Z | |
dc.date.available | 2024-04-30T12:48:44Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2234-943X | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199546 | |
dc.description.abstractEn | The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that, in cellulo , the substitution of S184 by a non-phosphorylatable residue stimulates both the mitochondrial localization of Bax, cytochrome c release, and apoptosis. However, in in vitro experiments, substituted mutants did not exhibit any increase in their binding capacity to isolated mitochondria or liposomes. Despite exhibiting a significant increase of the 6A7 epitope exposure, substituted mutants remain limited in their ability to form large oligomers, suggesting that they high capacity to promote apoptosis in cells was more related to a high content than to an increased ability to form large pores in the outer mitochondrial membranes. | |
dc.language.iso | EN | en_US |
dc.title.en | Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.3389/fonc.2022.1068994 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC] | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire | en_US |
bordeaux.journal | Frontiers in Oncology | en_US |
bordeaux.volume | 12 | en_US |
bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | Bordeaux INP | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | hal | |
hal.identifier | hal-04255643 | |
hal.version | 1 | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Oncology&rft.date=2023&rft.volume=12&rft.eissn=2234-943X&rft.issn=2234-943X&rft.au=SIMONYAN,%20Lilit&GONIN,%20Mathilde&HANKS,%20James&FRIEDLEIN,%20Jordan&DUTREC,%20Kevin&rft.genre=article |
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