Effects of Dendrimer-microRNA Nanoformulations against Glioblastoma Stem Cells
| dc.rights.license | open | en_US |
| dc.contributor.author | KNAUER, Nadezhda | |
| dc.contributor.author | MESCHANINOVA, Mariya | |
| dc.contributor.author | MUHAMMAD, Sajjad | |
| dc.contributor.author | HANGGI, Daniel | |
| dc.contributor.author | MAJORAL, Jean-Pierre | |
| dc.contributor.author | KAHLERT, Ulf | |
| dc.contributor.author | KOZLOV, Vladimir | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | APARTSIN, Evgeny | |
| dc.date.accessioned | 2024-04-30T08:37:25Z | |
| dc.date.available | 2024-04-30T08:37:25Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 1999-4923 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199522 | |
| dc.description.abstractEn | Glioblastoma is a rapidly progressing tumor quite resistant to conventional treatment. These features are currently assigned to a self-sustaining population of glioblastoma stem cells. Anti-tumor stem cell therapy calls for a new means of treatment. In particular, microRNA-based treatment is a solution, which in turn requires specific carriers for intracellular delivery of functional oligonucleotides. Herein, we report a preclinical in vitro validation of antitumor activity of nanoformulations containing antitumor microRNA miR-34a and microRNA-21 synthetic inhibitor and polycationic phosphorus and carbosilane dendrimers. The testing was carried out in a panel of glioblastoma and glioma cell lines, glioblastoma stem-like cells and induced pluripotent stem cells. We have shown dendrimer-microRNA nanoformulations to induce cell death in a controllable manner, with cytotoxic effects being more pronounced in tumor cells than in non-tumor stem cells. Furthermore, nanoformulations affected the expression of proteins responsible for interactions between the tumor and its immune microenvironment: surface markers (PD-L1, TIM3, CD47) and IL-10. Our findings evidence the potential of dendrimer-based therapeutic constructions for the anti-tumor stem cell therapy worth further investigation. | |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | Dendrimers | |
| dc.subject.en | MicroRNA | |
| dc.subject.en | Nucleic acid therapeutics | |
| dc.subject.en | 3D tumor models | |
| dc.subject.en | Glioblastoma | |
| dc.subject.en | Tumor stem cells | |
| dc.subject.en | Surface markers | |
| dc.subject.en | Nanomedicine | |
| dc.title.en | Effects of Dendrimer-microRNA Nanoformulations against Glioblastoma Stem Cells | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/pharmaceutics15030968 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Cancer | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie | en_US |
| bordeaux.journal | Pharmaceutics | en_US |
| bordeaux.page | 968 | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04174917 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pharmaceutics&rft.date=2023&rft.volume=15&rft.issue=3&rft.spage=968&rft.epage=968&rft.eissn=1999-4923&rft.issn=1999-4923&rft.au=KNAUER,%20Nadezhda&MESCHANINOVA,%20Mariya&MUHAMMAD,%20Sajjad&HANGGI,%20Daniel&MAJORAL,%20Jean-Pierre&rft.genre=article |
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