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Magnetic Polyion Complex Micelles for Cell Toxicity Induced by Radiofrequency Magnetic Field Hyperthermia

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierUniversity of Waterloo [Waterloo]
dc.contributor.authorNGUYEN, Vo-Thu
hal.structure.identifierLaboratory of Mammalian Cell Culture [GIGA-R]
hal.structure.identifierUniversité de Liège
dc.contributor.authorDE PAUW-GILLET, Marie-Claire
hal.structure.identifierUniversity of Waterloo [Waterloo]
dc.contributor.authorGAUTHIER, Mario
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2018
dc.identifier.issn2076-4991
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19940
dc.description.abstractEnMagnetic nanoparticles (MNPs) of magnetite (Fe3O4) were prepared using a polystyrene-graft-poly(2-vinylpyridine) copolymer (denoted G0PS-g-P2VP or G1) as template. These MNPs were subjected to self-assembly with a poly(acrylic acid)-block-poly(2-hydroxyethyl acrylate) double-hydrophilic block copolymer (DHBC), PAA-b-PHEA, to form water-dispersible magnetic polyion complex (MPIC) micelles. Large Fe3O4 crystallites were visualized by transmission electron microscopy (TEM) and magnetic suspensions of MPIC micelles exhibited improved colloidal stability in aqueous environments over a wide pH and ionic strength range. Biological cells incubated for 48 h with MPIC micelles at the highest concentration (1250 µg of Fe3O4 per mL) had a cell viability of 91%, as compared with 51% when incubated with bare (unprotected) MNPs. Cell internalization, visualized by confocal laser scanning microscopy (CLSM) and TEM, exhibited strong dependence on the MPIC micelle concentration and incubation time, as also evidenced by fluorescence-activated cell sorting (FACS). The usefulness of MPIC micelles for cellular radiofrequency magnetic field hyperthermia (MFH) was also confirmed, as the MPIC micelles showed a dual dose-dependent effect (concentration and duration of magnetic field exposure) on the viability of L929 mouse fibroblasts and U87 human glioblastoma epithelial cells.
dc.description.sponsorshipMagnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enmagnetic field hyperthermia
dc.subject.encell internalization
dc.subject.encytotoxicity
dc.subject.endouble-hydrophilic block copolymer
dc.subject.enarborescent polymer
dc.subject.enMagnetic Intra-Lysosomal Hyperthermia
dc.subject.enmagnetic nanoparticles
dc.subject.enmagnetic polyion complex micelle
dc.title.enMagnetic Polyion Complex Micelles for Cell Toxicity Induced by Radiofrequency Magnetic Field Hyperthermia
dc.typeArticle de revue
dc.identifier.doi10.3390/nano8121014
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
dc.description.sponsorshipEuropeErasmus Mundus - International Doctoral School in Functional Materials
dc.description.sponsorshipEuropeMultifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy
bordeaux.journalNanomaterials
bordeaux.page1014
bordeaux.volume8
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue12
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01948287
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01948287v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanomaterials&rft.date=2018&rft.volume=8&rft.issue=12&rft.spage=1014&rft.epage=1014&rft.eissn=2076-4991&rft.issn=2076-4991&rft.au=NGUYEN,%20Vo-Thu&DE%20PAUW-GILLET,%20Marie-Claire&GAUTHIER,%20Mario&SANDRE,%20Olivier&rft.genre=article


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