Structure of a heteropolymeric type 4 pilus from a monoderm bacterium
dc.rights.license | open | en_US |
hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
dc.contributor.author | ANGER, Robin | |
hal.structure.identifier | Laboratoire de chimie bactérienne [LCB] | |
dc.contributor.author | PIEULLE, Laetitia | |
hal.structure.identifier | MRC Centre for Molecular Microbiology and Infection [Imperial College, London] [CMBI] | |
dc.contributor.author | SHAHIN, Meriam | |
hal.structure.identifier | Laboratoire de chimie bactérienne [LCB] | |
hal.structure.identifier | Institut de Microbiologie de la Méditerranée [IMM] | |
dc.contributor.author | VALETTE, Odile | |
hal.structure.identifier | Institut de Microbiologie de la Méditerranée [IMM] | |
dc.contributor.author | LE GUENNO, Hugo | |
hal.structure.identifier | Institut de Microbiologie de la Méditerranée [IMM] | |
dc.contributor.author | KOSTA, Artemis | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
hal.structure.identifier | Laboratoire de chimie bactérienne [LCB] | |
dc.contributor.author | PELICIC, Vladimir | |
hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
dc.contributor.author | FRONZES, Remi | |
dc.date.accessioned | 2024-04-24T12:01:48Z | |
dc.date.available | 2024-04-24T12:01:48Z | |
dc.date.issued | 2023-12 | |
dc.identifier.issn | 2041-1723 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199316 | |
dc.description.abstractEn | Abstract Type 4 pili (T4P) are important virulence factors, which belong to a superfamily of nanomachines ubiquitous in prokaryotes, called type 4 filaments (T4F). T4F are defined as helical polymers of type 4 pilins. Recent advances in cryo-electron microscopy (cryo-EM) led to structures of several T4F, revealing that the long N-terminal α-helix (α1) – the trademark of pilins – packs in the centre of the filaments to form a hydrophobic core. In diderm bacteria – all available bacterial T4F structures are from diderm species – a portion of α1 is melted (unfolded). Here we report that this architecture is conserved in phylogenetically distant monoderm species by determining the structure of Streptococcus sanguinis T4P. Our 3.7 Å resolution cryo-EM structure of S. sanguinis heteropolymeric T4P and the resulting full atomic model including all minor pilins highlight universal features of bacterial T4F and have widespread implications in understanding T4F biology. | |
dc.description.sponsorship | Analyse structure/fonction du pilus Com, nanomachine filamenteuse répandue chez les bactéries monodermes, dédiée à la capture d'ADN - ANR-21-CE11-0008 | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title.en | Structure of a heteropolymeric type 4 pilus from a monoderm bacterium | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41467-023-42872-5 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
dc.identifier.pubmed | 37932265 | en_US |
bordeaux.journal | Nature Communications | en_US |
bordeaux.page | 7143 | en_US |
bordeaux.volume | 14 | en_US |
bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | hal | |
hal.identifier | hal-04278370 | |
hal.version | 1 | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | Pas de Licence CC | en_US |
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