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Hollow helices as high-affinity hosts: Single and double helical pseudofoldaxanes

dc.rights.licenseopenen_US
dc.contributor.authorZHONG, Yulong
dc.contributor.authorSOBIECH, Thomas
hal.structure.identifierSoutien à la Recherche de l'Institut Européen de Chimie Biologique
dc.contributor.authorKAUFFMANN, Brice
dc.contributor.authorSONG, Bo
dc.contributor.authorLI, Xiaopeng
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFERRAND, Yann
dc.contributor.authorHUC, Ivan
dc.contributor.authorGONG, Bing
dc.date.accessioned2024-04-23T10:01:12Z
dc.date.available2024-04-23T10:01:12Z
dc.date.issued2023-05-10
dc.identifier.issn2041-6520en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199275
dc.description.abstractEnTwo aromatic oligoamides, the 8-residue H8 and 16-residue H16, that adopt stable, cavity-containing helical conformations were examined for their complexation of rodlike dicationic guest, octyl viologen (OV 2+) and parabis(trimethylammonium)benzene (TB 2+). Studies based on 1D and 2D 1 H NMR, isothermal titration calorimetry (ITC), and Xray crystallography demonstrated that H8 and H16 wraps around two OV 2+ ions as a double helix and a single helix, respectively, resulting in 2:2 and 1:2 complexes. Compared to H8, the longer H16 binds the OV 2+ ions in much higher binding affinity and with extraordinary negative cooperativity. In contrast to its 1:2 binding with OV 2+ , the binding of helix H16 with the bulkier guest TB 2+ shows the same affinity but with a 1:1 ratio. This novel host-guest system is featured by the pairwise placement of otherwise strongly repulsive OV 2+ ions in the same cavity, strong negative cooperativity, and mutual adaptability of hosts and guests. The resultant 2:2, 1:2, and 1:1 complexes are highly stable pseudofoldaxanes with few known precedents. a.
dc.language.isoENen_US
dc.title.enHollow helices as high-affinity hosts: Single and double helical pseudofoldaxanes
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/d3sc00524ken_US
dc.subject.halChimieen_US
bordeaux.journalChemical Scienceen_US
bordeaux.page4759-4768en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue18en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04260528
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemical%20Science&rft.date=2023-05-10&rft.volume=14&rft.issue=18&rft.spage=4759-4768&rft.epage=4759-4768&rft.eissn=2041-6520&rft.issn=2041-6520&rft.au=ZHONG,%20Yulong&SOBIECH,%20Thomas&KAUFFMANN,%20Brice&SONG,%20Bo&LI,%20Xiaopeng&rft.genre=article


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