Afficher la notice abrégée

Prediction of the penetration depth of multi-lamellar liposomes in artificial skin. Application to the vectorization of corticosteroid in human skin

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorBERNASQUE, Antoine
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorCARIO, Muriel
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLECOMTE, Sophie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFAURE, Chrystel
dc.date.accessioned2024-04-19T06:47:10Z
dc.date.available2024-04-19T06:47:10Z
dc.date.issued2023-10
dc.identifier.issn0939-6411en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199231
dc.description.abstractEnOur previous work showed that the size, elasticity and charge of multi-lamellar liposomes (MLLs) could not be considered separately to predict the fate of MLLs in the skin [1]. Based on this study, we developed several MLLs formulations containing a corticosteroid, betamethasone 17-valerate (B17) to transport the drug into the stratum corneum, living epidermis, dermis or through the skin. MLLs encapsulation efficiency was found to exceed 74 +/- 3 % in all cases. In addition, we showed that MLLs protected the corticosteroid from thermal degradation. Comparing the penetration depth of all MLLs within artificial skin measured by Raman imaging, we established an equation for its determination, given the MLLs elasticity and size. This equation was verified experimentally on human explants: quantification of B17 in each skin layer, as well as its transdermal passage by ultra-high performance liquid chromatography, confirmed that B17 was predominantly and significantly transported in the desired layer. Eventually, we showed the benefits in using B17-loaded MLLs instead of a B17-containing pharmaceutical cream in terms of B17 penetration and thermal degradation.
dc.language.isoENen_US
dc.subject.enThermal protection
dc.subject.enSkin penetration prediction
dc.subject.enRaman imaging
dc.subject.enBetamethasone-17-valerate skin distribution
dc.subject.enMulti -lamellar liposomes
dc.title.enPrediction of the penetration depth of multi-lamellar liposomes in artificial skin. Application to the vectorization of corticosteroid in human skin
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ejpb.2023.09.007en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalEuropean Journal of Pharmaceutics and Biopharmaceuticsen_US
bordeaux.page303-314en_US
bordeaux.volume191en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04290840
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Pharmaceutics%20and%20Biopharmaceutics&rft.date=2023-10&rft.volume=191&rft.spage=303-314&rft.epage=303-314&rft.eissn=0939-6411&rft.issn=0939-6411&rft.au=BERNASQUE,%20Antoine&CARIO,%20Muriel&KRISA,%20Stephanie&LECOMTE,%20Sophie&FAURE,%20Chrystel&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée