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dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAILLON, Lucie
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorSOW, Mohamedou
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGOTREAU, Salomé
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.date.accessioned2024-04-16T09:42:29Z
dc.date.available2024-04-16T09:42:29Z
dc.date.issued2013-12-13
dc.identifier.issn0013-936Xen_US
dc.identifier.urihttps://www.researchgate.net/publication/259313507_Effect_of_Low-Dose_Cadmium_Exposure_on_DNA_Methylation_in_the_Endangered_European_Eel
dc.identifier.urioai:crossref.org:10.1021/es4048347
dc.identifier.urioai:researchgate.net:259313507
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199087
dc.description.abstractEnThere is increasing evidence that epigenetics can play a key role in the etiology of diseases engendered by chronic pollutant exposure. Although epigenetics has received significant attention in the field of biomedicine during the last years, epigenetics research is surprisingly very limited in ecotoxicology. The aim of the present study was to investigate the possible effects of low-dose cadmium exposure on the DNA methylation profile in a critically endangered fish species, the European eel. Eels were exposed to environmentally realistic concentrations of cadmium (0.4 and 4 µg.L-1) during 45 days. The global CpG methylation status of eel liver was determined by means of a home-made ELISA assay. We then used a methylation-sensitive arbitrarily primed PCR method to identify genes that are differentially methylated between control and Cd-exposed eels. Our results show that cadmium exposure is associated with DNA hypermethylation and with a decrease in total RNA synthesis. Among hypermethylated sequences identified, several fragments presented high homologies with genes encoding for proteins involved in intracellular trafficking, lipid biosynthesis and phosphatidic acid signaling pathway. In addition, few fragments presented high homologies with retrotransposon-like sequences. Our study illustrates how DNA methylation can be involved in the chronic stress response to Cd in fish.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceresearchgate
dc.title.enEffect of Low-Dose Cadmium Exposure on DNA Methylation in the Endangered European Eel
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/es4048347en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEnvironmental Science and Technologyen_US
bordeaux.page797-803en_US
bordeaux.volume48en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Technology&rft.date=2013-12-13&rft.volume=48&rft.issue=1&rft.spage=797-803&rft.epage=797-803&rft.eissn=0013-936X&rft.issn=0013-936X&rft.au=PIERRON,%20Fabien&BAILLON,%20Lucie&SOW,%20Mohamedou&GOTREAU,%20Salom%C3%A9&GONZALEZ,%20Patrice&rft.genre=article


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