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Mixing Block Copolymers with Phospholipids at the Nanoscale: From Hybrid Polymer/Lipid Wormlike Micelles to Vesicles Presenting Lipid Nanodomains

dc.rights.licenseopen
hal.structure.identifierCHU Caen
dc.contributor.authorDAO, T.
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
hal.structure.identifierLLB - Infrastructures et développement [INFRA]
dc.contributor.authorBRULET, A.
hal.structure.identifierCQFM-Centro de Química-FísicaMolecular and IN-Institute for Nanosciences and Nanotechnologies, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa
dc.contributor.authorFERNANDES, F.
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorER-RAFIK, M.
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorFERJI, Khalid
hal.structure.identifierInstitut Laue-Langevin [ILL]
dc.contributor.authorSCHWEINS, R.
hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
dc.contributor.authorCHAPEL, Jean-Paul
hal.structure.identifierInstitut de recherche en astrophysique et planétologie [IRAP]
dc.contributor.authorFEDOROV, A.
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorSCHMUTZ, M.
hal.structure.identifierCentro de Química-Física Molecular
dc.contributor.authorPRIETO, M.
hal.structure.identifierPhysicochimie des Electrolytes, Colloïdes et Sciences Analytiques [PECSA]
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLE MEINS, Jean-Francois
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn0743-7463
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19904
dc.description.abstractEnHybrids, i.e., intimately mixed polymer/phospholipid vesicles, can potentially marry in a single membrane the best characteristics of the two separate components. The ability of amphiphilic copolymers and phospholipids to self-assemble into hybrid membranes has been studied until now on the submicrometer scale using optical microscopy on giant hybrid unilamellar vesicles (GHUVs), but limited information is available on large hybrid unilamellar vesicles (LHUVs). In this work, copolymers based on poly(dimethylsiloxane) and poly(ethylene oxide) with different molar masses and architectures (graft, triblock) were associated with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Classical protocols of LUV formation were used to obtain nanosized self-assembled structures. Using small-angle neutron scattering (SANS), time-resolved Förster resonance energy transfer (TR-FRET), and cryo-transmission electron microscopy (cryo-TEM), we show that copolymer architecture and molar mass have direct influences on the formation of hybrid nanostructures that can range from wormlike hybrid micelles to hybrid vesicles presenting small lipid nanodomains.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enMixing Block Copolymers with Phospholipids at the Nanoscale: From Hybrid Polymer/Lipid Wormlike Micelles to Vesicles Presenting Lipid Nanodomains
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.langmuir.6b04478
dc.subject.halChimie/Polymères
bordeaux.journalLangmuir
bordeaux.page1705-1715
bordeaux.volume33
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue7
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02056836
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02056836v1
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