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Genotoxic and stress inductive potential of Cadmium in Xenopus laevis larvae.

dc.contributor.authorMOUCHET, Florence
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
IDREF: 105696722
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorCUENOT, Y.
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBOURDINEAUD, Jean-Paul
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBOUDOU, Alain
dc.contributor.authorGAUTHIER, Laury
dc.date.accessioned2024-04-15T15:34:25Z
dc.date.available2024-04-15T15:34:25Z
dc.date.issued2006-06-15
dc.identifier.issn0166-445X
dc.identifier.urihttps://hal.archives-ouvertes.fr/hal-00131211
dc.identifier.urioai:researchgate.net:7164620
dc.identifier.urioai:crossref.org:10.1016/j.aquatox.2006.02.029
dc.identifier.uriftutoulouse3hal:oai:HAL:hal-00131211v1
dc.identifier.urioadoi:http://oatao.univ-toulouse.fr/5745/1/Gauthier_5745.pdf
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199018
dc.description.abstractEnThe present investigation evaluates the toxic potential of Cd in larvae of the frog Xenopus laevis after 12 days of exposure to environmentally relevant contamination levels, close to those measured in the river Lot (France). Several genotoxic and detoxification mechanisms were analyzed in the larvae: clastogenic and/or aneugenic effects in the circulating blood by micronucleus (MN) induction, metallothionein (MT) production in whole larvae, gene analyses and Cd content in the liver and also in the whole larvae. The results show: (i) micronucleus induction at environmental levels of Cd contamination (2, 10, 30 microgL(-1)); (ii) an increased and concentration-dependent quantity of MT in the whole organism after contamination with 10 and 30 microgCdL(-1) (a three- and six-fold increase, respectively) although no significant difference was observed after contamination with 2 microgCdL(-1); (iii) Cd uptake by the whole organism and by the liver as a response to Cd exposure conditions; (4) up-regulation of the genes involved in detoxification processes and response to oxidative stress, while genes involved in DNA repair and apoptosis were repressed. The results confirm the relevance of the amphibian model and highlight the complementarity between a marker of genotoxicity, MT production, bioaccumulation and genetic analysis in the evaluation of the ecotoxicological impact.
dc.publisherElsevier BV
dc.sourceresearchgate
dc.sourcecrossref
dc.sourcebase
dc.sourceoadoi_repo
dc.subject.meshSciences de l'environnement
dc.title.enGenotoxic and stress inductive potential of Cadmium in Xenopus laevis larvae.
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.aquatox.2006.02.029
bordeaux.journalAquatic Toxicologyen_US
bordeaux.page157-166
bordeaux.volume78
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aquatic%20Toxicology&rft.date=2006-06-15&rft.volume=78&rft.issue=2&rft.spage=157-166&rft.epage=157-166&rft.eissn=0166-445X&rft.issn=0166-445X&rft.au=MOUCHET,%20Florence&BAUDRIMONT,%20Magalie&GONZALEZ,%20Patrice&CUENOT,%20Y.&BOURDINEAUD,%20Jean-Paul&rft.genre=article


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