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Diversity and variability of NOD-like receptors in fungi

hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorDYRKA, Witold
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorLAMACCHIA, Marina
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorDURRENS, Pascal
hal.structure.identifierInstitute for Molecular Bioscience and Centre for Infectious Disease Research, University of Queensland
dc.contributor.authorKOBE, Bostjan
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorDASKALOV, Asen
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorPAOLETTI, Matthieu
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorSHERMAN, David J
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorSAUPE, Sven J
dc.date.accessioned2024-04-15T09:57:50Z
dc.date.available2024-04-15T09:57:50Z
dc.date.created2014-11-13
dc.date.issued2014-11-13
dc.identifier.issn1759-6653
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/198952
dc.description.abstractEnNOD-like receptors (NLRs) are intracellular receptors that control innate immunity and other biotic interactions in animals and plants. NLRs have been characterized in plant and animal lineages, but in fungi, this gene family has not been systematically described. There is however previous indications of the involvement of NLR-like genes in non-self recognition and programmed cell death in fungi. We have analyzed 198 fungal genomes for the presence of NLRs and have annotated a total of 5616 NLR candidates. We describe their phylogenetic distribution, domain organization and evolution. Fungal NLRs are characterized by a great diversity of domain organizations, suggesting frequently occurring combinatorial assortments of different effector, NOD and repeat domains. The repeat domains are of the WD, ANK and TPR type; no LRR motifs were found. As previously documented for WD-repeat domains of fungal NLRs, TPR and ANK repeats evolve under positive selection and show highly conserved repeats and repeat length polymorphism, suggesting the possibility of concerted evolution of these repeats. We identify novel effector domains not previously found associated with NLRs, while others are related to effector domains of plant or animals NLRs. In particular, we show that the HET domain found in fungal NLRs may be related to TIR domains found in animal and plant immune receptors. This description of fungal NLR repertoires reveals both similarities and differences with plant and animals NLR collections, highlights the importance of domain re-assortment and repeat evolution and provides a novel entry point to explore the evolution of NLRs in eukaryotes.
dc.description.sponsorshipReconnaissance hétérospécifique chez les champignons filamenteux : Des récepteurs à la réponse cellulaire - ANR-11-BSV3-0019
dc.language.isoen
dc.publisherSociety for Molecular Biology and Evolution
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enDiversity and variability of NOD-like receptors in fungi
dc.typeArticle de revue
dc.identifier.doi10.1093/gbe/evu251
dc.subject.halSciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
dc.subject.halSciences du Vivant [q-bio]/Biodiversité/Evolution [q-bio.PE]
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Immunité innée
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Mycologie
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
bordeaux.journalGenome Biology and Evolution
bordeaux.pagein press
bordeaux.hal.laboratoriesLaboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01083450
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01083450v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Genome%20Biology%20and%20Evolution&rft.date=2014-11-13&rft.spage=in%20press&rft.epage=in%20press&rft.eissn=1759-6653&rft.issn=1759-6653&rft.au=DYRKA,%20Witold&LAMACCHIA,%20Marina&DURRENS,%20Pascal&KOBE,%20Bostjan&DASKALOV,%20Asen&rft.genre=article


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