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Overlapping Podospora anserina transcriptional responses to bacterial and fungal non self indicate a multilayered innate immune response

hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorLAMACCHIA, Marina
hal.structure.identifierWroclaw University of Science and Technology
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorDYRKA, Witold
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorBRETON, Annick
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorSAUPE, Sven J
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorPAOLETTI, Mathieu
dc.date.accessioned2024-04-15T09:56:57Z
dc.date.available2024-04-15T09:56:57Z
dc.date.issued2016
dc.identifier.issn1664-302X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/198878
dc.description.abstractEnRecognition and response to non self is essential to development and survival of all organisms. It can occur between individuals of the same species or between different organisms. Fungi are established models for conspecific non self recognition in the form of vegetative incompatibility (VI), a genetically controlled process initiating a programmed cell death (PCD) leading to the rejection of a fusion cell between genetically different isolates of the same species. In Podospora anserina VI is controlled by members of the hnwd gene family encoding for proteins analogous to NOD Like Receptors (NLR) immune receptors in eukaryotes. It was hypothesized that the hnwd controlled VI reaction was derived from the fungal innate immune response. Here we analyze the P. anserina transcriptional responses to two bacterial species, Serratia fonticola to which P. anserina survives and S. marcescens to which P. anserina succumbs, and compare these to the transcriptional response induced under VI conditions. Transcriptional responses to both bacteria largely overlap, however the number of genes regulated and magnitude of regulation is more important when P. anserina survives. Transcriptional responses to bacteria also overlap with the VI reaction for both up or down regulated gene sets. Genes up regulated tend to be clustered in the genome, and display limited phylogenetic distribution. In all three responses we observed genes related to autophagy to be up-regulated. Autophagy contributes to the fungal survival in all three conditions. Genes encoding for secondary metabolites and histidine kinase signaling are also up regulated in all three conditions. Transcriptional responses also display differences. Genes involved in response to oxidative stress, or encoding small secreted proteins are essentially expressed in response to bacteria, while genes encoding NLR proteins are expressed during VI. Most functions encoded in response to bacteria favor survival of the fungus while most functions up regulated during VI would lead to cell death. These differences are discussed in the frame of a multilayered response to non self in fungi.
dc.description.sponsorshipReconnaissance hétérospécifique chez les champignons filamenteux : Des récepteurs à la réponse cellulaire - ANR-11-BSV3-0019
dc.language.isoen
dc.publisherFrontiers Media
dc.subject.enBacterial Fungal Interaction
dc.subject.enVegetative incompatibility
dc.subject.enPodospora anserina
dc.subject.enSerratia marcescens
dc.subject.enSerratia fonticola
dc.subject.enTranscriptome
dc.title.enOverlapping Podospora anserina transcriptional responses to bacterial and fungal non self indicate a multilayered innate immune response
dc.typeArticle de revue
dc.identifier.doi10.3389/fmicb.2016.00471
dc.subject.halSciences du Vivant [q-bio]/Ecologie, Environnement/Interactions entre organismes
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Immunité innée
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Mycologie
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
bordeaux.journalFrontiers in Microbiology
bordeaux.page471
bordeaux.volume7
bordeaux.hal.laboratoriesLaboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01293719
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01293719v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Microbiology&rft.date=2016&rft.volume=7&rft.spage=471&rft.epage=471&rft.eissn=1664-302X&rft.issn=1664-302X&rft.au=LAMACCHIA,%20Marina&DYRKA,%20Witold&BRETON,%20Annick&SAUPE,%20Sven%20J&PAOLETTI,%20Mathieu&rft.genre=article


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