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Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cerevisiae strains.

hal.structure.identifierFaculté d'Oenologie [Bordeaux II]
dc.contributor.authorMARULLO, Philippe
hal.structure.identifierLaboratoire de Biologie Moléculaire de la Cellule [LBMC]
dc.contributor.authorAIGLE, Michel
hal.structure.identifierFaculté d'Oenologie [Bordeaux II]
dc.contributor.authorBELY, Marina
hal.structure.identifierFaculté d'Oenologie [Bordeaux II]
dc.contributor.authorMASNEUF-POMAREDE, Isabelle
hal.structure.identifierFaculté d'Oenologie [Bordeaux II]
hal.structure.identifierModels and Algorithms for the Genome [MAGNOME]
dc.contributor.authorDURRENS, Pascal
hal.structure.identifierFaculté d'Oenologie [Bordeaux II]
dc.contributor.authorDUBOURDIEU, Denis
hal.structure.identifierLaboratoire de Biologie Moléculaire de la Cellule [LBMC]
dc.contributor.authorYVERT, Gaël
dc.date.accessioned2024-04-15T09:56:27Z
dc.date.available2024-04-15T09:56:27Z
dc.date.issued2007
dc.identifier.issn1567-1356
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/198836
dc.description.abstractEnNatural Saccharomyces cerevisiae yeast strains exhibit very large genotypic and phenotypic diversity. However, the link between phenotype variation and genetic determinism is still difficult to identify, especially in wild populations. Using genome hybridization on DNA microarrays, it is now possible to identify single-feature polymorphisms among divergent yeast strains. This tool offers the possibility of applying quantitative genetics to wild yeast strains. In this instance, we studied the genetic basis for variations in acetic acid production using progeny derived from two strains from grape must isolates. The trait was quantified during alcoholic fermentation of the two strains and 108 segregants derived from their crossing. A genetic map of 2212 markers was generated using oligonucleotide microarrays, and a major quantitative trait locus (QTL) was mapped with high significance. Further investigations showed that this QTL was due to a nonsynonymous single-nucleotide polymorphism that targeted the catalytic core of asparaginase type I (ASP1) and abolished its activity. This QTL was only effective when asparagine was used as a major nitrogen source. Our results link nitrogen assimilation and CO(2) production rate to acetic acid production, as well as, on a broader scale, illustrating the specific problem of quantitative genetics when working with nonlaboratory microorganisms.
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.enQTL mapping
dc.subject.enDNA microarray
dc.subject.enacetic acid
dc.subject.enwine fermentation
dc.subject.enaneuploidy
dc.subject.enASP1
dc.title.enSingle QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cerevisiae strains.
dc.typeArticle de revue
dc.identifier.doi10.1111/j.1567-1364.2007.00252.x
dc.subject.halSciences du Vivant [q-bio]/Génétique
bordeaux.journalFEMS Yeast Research
bordeaux.page941-952
bordeaux.volume7
bordeaux.hal.laboratoriesLaboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800*
bordeaux.issue7
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierensl-00181998
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//ensl-00181998v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=FEMS%20Yeast%20Research&rft.date=2007&rft.volume=7&rft.issue=7&rft.spage=941-952&rft.epage=941-952&rft.eissn=1567-1356&rft.issn=1567-1356&rft.au=MARULLO,%20Philippe&AIGLE,%20Michel&BELY,%20Marina&MASNEUF-POMAREDE,%20Isabelle&DURRENS,%20Pascal&rft.genre=article


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