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Polypeptide Nanoparticles Obtained from Emulsion Polymerization of Amino Acid N-Carboxyanhydrides

dc.rights.licenseopen
dc.contributor.authorJACOBS, Jaco
hal.structure.identifierRoyal College of Surgeons in Ireland [RCSI]
dc.contributor.authorPAVLOVIĆ, Dražen
hal.structure.identifierRoyal College of Surgeons in Ireland [RCSI]
dc.contributor.authorPRYDDERCH, Hannah
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
dc.contributor.authorMORADI, Mohammad-Amin
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
dc.contributor.authorHEUTS, Johan
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierRoyal College of Surgeons in Ireland [RCSI]
dc.contributor.authorHEISE, Andreas
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2019
dc.identifier.issn0002-7863
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19838
dc.description.abstractEnPolypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-l-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enAmino Acid N-Carboxyanhydrides
dc.subject.enPolypeptides
dc.subject.enEmulsion Polymerization
dc.title.enPolypeptide Nanoparticles Obtained from Emulsion Polymerization of Amino Acid N-Carboxyanhydrides
dc.typeArticle de revue
dc.identifier.doi10.1021/jacs.9b06750
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalJournal of the American Chemical Society
bordeaux.page12522-12526
bordeaux.volume141
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue32
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02239076
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02239076v1
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