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Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains.

hal.structure.identifierDepartment of Biotechnology [Delft]
dc.contributor.authorCANELAS, André B
hal.structure.identifierCambridge Systems Biology Centre & Department of Biochemistry [CSBC]
dc.contributor.authorHARRISON, Nicola
hal.structure.identifierDanmarks Tekniske Universitet = Technical University of Denmark [DTU]
dc.contributor.authorFAZIO, Alessandro
hal.structure.identifierCentre for Wireless Network Design [CWIND]
hal.structure.identifierChalmers University of Technology [Göteborg]
dc.contributor.authorZHANG, Jie
hal.structure.identifierTechnical Research Centre of Finland
dc.contributor.authorPITKÄNEN, Juha-Pekka
hal.structure.identifierDepartment of Biotechnology [Delft]
dc.contributor.authorVAN DEN BRINK, Joost
hal.structure.identifierDepartment of Molecular Cell Physiology [VU Amsterdam]
dc.contributor.authorBAKKER, Barbara M
hal.structure.identifierUniversity of Stuttgart
dc.contributor.authorBOGNER, Lara
hal.structure.identifierDepartment of Molecular Cell Physiology [VU Amsterdam]
dc.contributor.authorBOUWMAN, Jildau
hal.structure.identifierCambridge Systems Biology Centre & Department of Biochemistry [CSBC]
dc.contributor.authorCASTRILLO, Juan I
hal.structure.identifierDepartment of Chemical Engineering [Bogazici] [ChE]
dc.contributor.authorCANKORUR, Ayca
hal.structure.identifierChalmers University of Technology [Göteborg]
dc.contributor.authorCHUMNANPUEN, Pramote
hal.structure.identifierDepartment of Biotechnology [Delft]
dc.contributor.authorDARAN-LAPUJADE, Pascale
hal.structure.identifierDepartment of Chemical Engineering [Bogazici] [ChE]
dc.contributor.authorDIKICIOGLU, Duygu
hal.structure.identifierDepartment of Molecular Cell Physiology [VU Amsterdam]
dc.contributor.authorVAN EUNEN, Karen
hal.structure.identifierInstitute for Molecular Systems Biology [ETH Zurich] [IMSB]
dc.contributor.authorEWALD, Jennifer C
hal.structure.identifierDepartment of Biotechnology [Delft]
dc.contributor.authorHEIJNEN, Joseph J
hal.structure.identifierDepartment of Chemical Engineering [Bogazici] [ChE]
dc.contributor.authorKIRDAR, Betul
hal.structure.identifierTechnical Research Centre of Finland
dc.contributor.authorMATTILA, Ismo
hal.structure.identifierDepartment of Molecular Cell Physiology [VU Amsterdam]
dc.contributor.authorMENSONIDES, Femke I C
hal.structure.identifierUniversity of Stuttgart
dc.contributor.authorNIEBEL, Anja
hal.structure.identifierTechnical Research Centre of Finland
dc.contributor.authorPENTTILÄ, Merja
hal.structure.identifierDepartment of Biotechnology [Delft]
dc.contributor.authorPRONK, Jack T
hal.structure.identifierUniversity of Stuttgart
dc.contributor.authorREUSS, Matthias
hal.structure.identifierTechnical Research Centre of Finland
dc.contributor.authorSALUSJÄRVI, Laura
hal.structure.identifierInstitute for Molecular Systems Biology [ETH Zurich] [IMSB]
dc.contributor.authorSAUER, Uwe
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
hal.structure.identifierModèles et algorithmes pour la Bioinformatique et la Visualisation d'informations; [MABIOVIS]
dc.contributor.authorSHERMAN, David James
hal.structure.identifierUniversity of Stuttgart
dc.contributor.authorSIEMANN-HERZBERG, Martin
hal.structure.identifierDepartment of Molecular Cell Physiology [VU Amsterdam]
dc.contributor.authorWESTERHOFF, Hans
hal.structure.identifierDepartment of Biotechnology [Delft]
dc.contributor.authorDE WINDE, Johannes
hal.structure.identifierChalmers University of Technology [Göteborg]
dc.contributor.authorPETRANOVIC, Dina
hal.structure.identifierCambridge Systems Biology Centre & Department of Biochemistry [CSBC]
dc.contributor.authorOLIVER, Stephen G
hal.structure.identifierDanmarks Tekniske Universitet = Technical University of Denmark [DTU]
dc.contributor.authorWORKMAN, Christopher T
hal.structure.identifierInstitute for Molecular Systems Biology [ETH Zurich] [IMSB]
dc.contributor.authorZAMBONI, Nicola
hal.structure.identifierChalmers University of Technology [Göteborg]
dc.contributor.authorNIELSEN, Jens
dc.date.accessioned2024-04-15T09:47:55Z
dc.date.available2024-04-15T09:47:55Z
dc.date.issued2010-12
dc.identifier.issn2041-1723
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/198138
dc.description.abstractEnThe field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular components in the yeast Saccharomyces cerevisiae, a widely used model organism that is also used in the production of fuels, chemicals, food ingredients and pharmaceuticals. With the current focus on biofuels and sustainability, there is much interest in harnessing this species as a general cell factory. In this study, we characterized two yeast strains, under two standard growth conditions. We ensured the high quality of the experimental data by evaluating a wide range of sampling and analytical techniques. Here we show significant differences in the maximum specific growth rate and biomass yield between the two strains. On the basis of the integrated analysis of the high-throughput data, we hypothesize that differences in phenotype are due to differences in protein metabolism.
dc.language.isoen
dc.publisherNature Publishing Group
dc.title.enIntegrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains.
dc.typeArticle de revue
dc.identifier.doi10.1038/ncomms1150
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
dc.subject.halSciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
dc.description.sponsorshipEuropeYeast Systems Biology Network
bordeaux.journalNature Communications
bordeaux.page145
bordeaux.volume1
bordeaux.hal.laboratoriesLaboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800*
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierinria-00562005
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//inria-00562005v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2010-12&rft.volume=1&rft.issue=9&rft.spage=145&rft.epage=145&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=CANELAS,%20Andr%C3%A9%20B&HARRISON,%20Nicola&FAZIO,%20Alessandro&ZHANG,%20Jie&PITK%C3%84NEN,%20Juha-Pekka&rft.genre=article


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