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Reusing and composing models of cell fate regulation of human bone precursor cells.

hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
hal.structure.identifierCenter for Genome Regulation [Santiago] [CGR]
dc.contributor.authorASSAR, Rodrigo
hal.structure.identifierHematology-Oncology Department School of Medicine
dc.contributor.authorLEISEWITZ, Andrea V
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorGARCIA, Alice
hal.structure.identifierCentro de Regulación Celular y Patología Joaquín V. Luco, Departamento de Biología Celular y Molecular [CRCP]
dc.contributor.authorINESTROSA, Nibaldo C
hal.structure.identifierCenter for Genome Regulation [Santiago] [CGR]
hal.structure.identifierCentro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas and Facultad de Medicina
dc.contributor.authorMONTECINO, Martín A
hal.structure.identifierModels and Algorithms for the Genome [ MAGNOME]
dc.contributor.authorSHERMAN, David James
dc.date.accessioned2024-04-15T09:45:40Z
dc.date.available2024-04-15T09:45:40Z
dc.date.issued2012-04
dc.identifier.issn0303-2647
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197940
dc.description.abstractEnIn order to treat osteoporosis and other bone mass disorders it is necessary to understand the regulatory processes that control the cell fate decisions responsible for going from bone precursor cells to bone tissue. Many processes interact to regulate cell division, differentiation and apoptosis. There are models for these basic processes, but not for their interactions. In this work we use the theory of switched systems, reuse and composition of validated models to describe the cell fate decisions leading to bone and fat formation. We describe the differentiation of osteo-adipo progenitor cells by composing its model with differentiation stimuli. We use the activation of the Wnt pathway as stimulus to osteoblast lineage, including regulation of cell division and apoptosis. This model is our first step to simulate physiological responses in silico to treatments for bone mass disorders.
dc.language.isoen
dc.publisherElsevier
dc.subject.enBone formation
dc.subject.enDifferentiation
dc.subject.enWnt pathway
dc.title.enReusing and composing models of cell fate regulation of human bone precursor cells.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.biosystems.2012.01.008
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
dc.subject.halSciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire
bordeaux.journalBioSystems
bordeaux.page63-72
bordeaux.volume108
bordeaux.hal.laboratoriesLaboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800*
bordeaux.issue1-3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00681022
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00681022v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BioSystems&rft.date=2012-04&rft.volume=108&rft.issue=1-3&rft.spage=63-72&rft.epage=63-72&rft.eissn=0303-2647&rft.issn=0303-2647&rft.au=ASSAR,%20Rodrigo&LEISEWITZ,%20Andrea%20V&GARCIA,%20Alice&INESTROSA,%20Nibaldo%20C&MONTECINO,%20Mart%C3%ADn%20A&rft.genre=article


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