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hal.structure.identifierInteractions moléculaires et réactivité chimique et photochimique [IMRCP]
dc.contributor.authorGINESTE, Stéphane
hal.structure.identifierEuropean Synchrotron Radiation Facility [ESRF]
dc.contributor.authorDI COLA, Emanuela
hal.structure.identifierInteractions moléculaires et réactivité chimique et photochimique [IMRCP]
dc.contributor.authorAMOUROUX, Baptiste
hal.structure.identifierInteractions moléculaires et réactivité chimique et photochimique [IMRCP]
dc.contributor.authorTILL, Ugo
hal.structure.identifierInteractions moléculaires et réactivité chimique et photochimique [IMRCP]
dc.contributor.authorMARTY, Jean-Daniel
hal.structure.identifierInteractions moléculaires et réactivité chimique et photochimique [IMRCP]
dc.contributor.authorMINGOTAUD, Anne-Françoise
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorMINGOTAUD, Christophe
hal.structure.identifierChimie Agro-Industrielle [CAI]
dc.contributor.authorVIOLLEAU, Frédéric
dc.contributor.authorBERTI, Ugo
dc.contributor.authorPARIGI, Ugo
dc.contributor.authorLUCHINAT, Ugo
hal.structure.identifierCentre de Microscopie Électronique Appliquée à la Biologie [CMEAB]
dc.contributor.authorBALOR, Stephanie
dc.contributor.authorMARTY, Michael
hal.structure.identifierInteractions moléculaires et réactivité chimique et photochimique [IMRCP]
dc.contributor.authorLONETTI, Barbara
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2018
dc.identifier.issn0024-9297
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19790
dc.description.abstractEnPolyion complex (PIC) micelles formed from the electrostatic interaction between oppositely charged polymers have been studied for their promising applications in the biomedical field as drug carriers or vectors for gene delivery. In spite of their asset of possible high drug loading, their formation process remains poorly studied. In this work, we investigate the properties of a series of PICs based on poly(ethylene oxide-b-acrylic acid) (PEO–PAA)/dendrigraft poly(L-lysine) (DGL3), using PEO–PAA with different compositions and average molecular weights. For each PEO–PAA/DGL3 pair, the complexes were characterized as a function of the ratios between acid and amine moieties combining different techniques: dynamic light scattering (DLS), flow field-flow fractionation (FlFFF), small-angle X-ray scattering (SAXS), and relaxometry. The coupling of batch techniques, i.e., DLS, SAXS, and relaxometry, together with a soft separation technique like FlFFF enabled a finer analysis to elucidate subtle details of the association process and of the polydispersity of the complexes. We show that the formation of PICs is more complex than previously described. In particular, we demonstrate that PICs with stoichiometry 1:1 may form at low ratios provided that the acidic block is long enough to neutralize the cationic dendrigraft with few polymer chains. Moreover, in such conditions, PICs with stoichiometry 1:1 often coexist with free dendritic polymers and other associated complex species.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enPolyion Complex
dc.subject.enMacromolecules
dc.title.enMechanistic Insights into Polyion Complex Associations
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.macromol.7b02391
dc.subject.halChimie/Autre
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
bordeaux.journalMacromolecules
bordeaux.page1427-1440
bordeaux.volume51
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue4
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02171171
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02171171v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecules&rft.date=2018&rft.volume=51&rft.issue=4&rft.spage=1427-1440&rft.epage=1427-1440&rft.eissn=0024-9297&rft.issn=0024-9297&rft.au=GINESTE,%20St%C3%A9phane&DI%20COLA,%20Emanuela&AMOUROUX,%20Baptiste&TILL,%20Ugo&MARTY,%20Jean-Daniel&rft.genre=article


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