Development of a multi-residue method for scrutinizing psychotropic compounds in natural waters
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | BRIEUDES, Vincent | |
| hal.structure.identifier | Laboratoire National de métrologie et d’Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France | |
| dc.contributor.author | LARDY-FONTAN, S. | |
| hal.structure.identifier | Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France | |
| dc.contributor.author | VASLIN-REIMANN, S. | |
| hal.structure.identifier | Laboratoire de Physico et Toxico-Chimie des systèmes naturels [LPTC] | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | BUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154 IDREF: 070478090 | |
| hal.structure.identifier | Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France | |
| dc.contributor.author | LALERE, B. | |
| dc.date.accessioned | 2024-04-11T08:53:28Z | |
| dc.date.available | 2024-04-11T08:53:28Z | |
| dc.date.issued | 2017-03 | |
| dc.identifier.issn | 0378-4347 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/197519 | |
| dc.description.abstractEn | The present work describes a multi-residue SPE-UPLC–MS/MS method aiming at the characterization of 68 compounds in natural waters, including parent compounds as well as their major metabolites and glucuronide conjugates. Development was conducted toward the quantitative determination of a broad range of analytes belonging to different class of psychotropic drugs such as benzodiazepines, antidepressants, stimulants, opiates and opioids, anticonvulsants, anti-dementia drugs, analgesic and anti-inflammatory drugs (as anthropic indicators) in the low ng L−1 range of concentration. Satisfactory extraction recoveries >70% were obtained for the majority of analytes (49 out of 68) allowing low limits of quantification. LOQ ranged between 0.1 and 17.8 ng L−1 and were lower than 5 ng L−1 for 94% of investigated analytes. Furthermore, addition of 25 isotopic labeled standards allowed to ensure reliability of the optimized method. Quantification errors were typically below 15% with relative standard variations <10% in intermediate precision conditions. Finally, the developed method was implemented in natural waters; sampling campaigns were conducted in the Seine River as a demonstration of the applicability and adequation of the method for its purpose. As a result, 48 out of 68 analytes were identified or quantified; some of them like memantine, rivastigmine, zolpidem 4-phenyl-carboxylic acid, zolpidem 6-carboxylic acid for one of the first time in surface waters. Among investigated psychotropic compounds and metabolites, tramadol, codeine, oxazepam, venlafaxine, O-desmethylvenlafaxine, gabapentin, carbamazepine and 10,11-dihydro-10,11-dihydroxycarbamazepine were found to be the most abundant. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Pharmaceuticals | |
| dc.subject.en | Illicit drugs | |
| dc.subject.en | Metabolites | |
| dc.subject.en | Multi-residue | |
| dc.subject.en | Method development | |
| dc.subject.en | Isotope dilution | |
| dc.subject.en | SPE | |
| dc.subject.en | UPLC–MS/MS | |
| dc.subject.en | Surface water | |
| dc.subject.en | GEOF | |
| dc.title.en | Development of a multi-residue method for scrutinizing psychotropic compounds in natural waters | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jchromb.2016.07.016 | en_US |
| dc.subject.hal | Sciences de l'environnement | en_US |
| bordeaux.journal | Journal of Chromatography B Biomedical Sciences and Applications | en_US |
| bordeaux.page | 160-172 | en_US |
| bordeaux.volume | 1047 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | LPTC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03159670 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Chromatography%20B%20Biomedical%20Sciences%20and%20Applications&rft.date=2017-03&rft.volume=1047&rft.spage=160-172&rft.epage=160-172&rft.eissn=0378-4347&rft.issn=0378-4347&rft.au=BRIEUDES,%20Vincent&LARDY-FONTAN,%20S.&VASLIN-REIMANN,%20S.&BUDZINSKI,%20H%C3%A9l%C3%A8ne&LALERE,%20B.&rft.genre=article |
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