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Switchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes

dc.rights.licenseopen
hal.structure.identifierGene Delivery Laboratory
dc.contributor.authorPASSOS GIBSON, Victor
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorFAUQUIGNON, Martin
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierGene Delivery Laboratory
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorLEBLOND CHAIN, Jeanne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.issn2073-4360
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19715
dc.description.abstractEnBlending amphiphilic copolymers and lipids constitutes a novel approach to combine the advantages of polymersomes and liposomes into a new single hybrid membrane. Efforts have been made to design stimuli-responsive vesicles, in which the membrane’s dynamic is modulated by specific triggers. In this investigation, we proposed the design of pH-responsive hybrid vesicles formulated with poly(dimethylsiloxane)-block-poly(ethylene oxide) backbone (PDMS36-b-PEO23) and cationic switchable lipid (CSL). The latter undergoes a pH-triggered conformational change and induces membrane destabilization. Using confocal imaging and DLS measurements, we interrogated the structural changes in CSL-doped lipid and hybrid polymer/lipid unilamellar vesicles at the micro- and nanometric scale, respectively. Both switchable giant unilamellar lipid vesicles (GUV) and hybrid polymer/lipid unilamellar vesicles (GHUV) presented dynamic morphological changes, including protrusions and fission upon acidification. At the submicron scale, scattered intensity decreased for both switchable large unilamellar vesicles (LUV) and hybrid vesicles (LHUV) under acidic pH. Finally, monitoring the fluorescence leakage of encapsulated calcein, we attested that CSL increased the permeability of GUV and GHUV in a pH-specific fashion. Altogether, these results show that switchable lipids provide a pH-sensitive behavior to hybrid polymer/lipid vesicles that could be exploited for the triggered release of drugs, cell biomimicry studies, or as bioinspired micro/nanoreactors.
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.engiant hybrid polymer/lipid vesicles
dc.subject.enhybrid polymer/lipid membrane
dc.subject.enpH-sensitive liposomes
dc.subject.enswitchable lipid
dc.subject.engiant unilamellar vesicles
dc.subject.enresponsive vesicles
dc.title.enSwitchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes
dc.typeArticle de revue
dc.identifier.doi10.3390/polym12030637
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalPolymers
bordeaux.page637
bordeaux.volume12
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue3
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02506021
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02506021v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymers&rft.date=2020&rft.volume=12&rft.issue=3&rft.spage=637&rft.epage=637&rft.eissn=2073-4360&rft.issn=2073-4360&rft.au=PASSOS%20GIBSON,%20Victor&FAUQUIGNON,%20Martin&IBARBOURE,%20Emmanuel&LEBLOND%20CHAIN,%20Jeanne&LE%20MEINS,%20Jean-Francois&rft.genre=article


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