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Tear of Lipid Membranes by Nanoparticles

dc.rights.licenseopen
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorER-RAFIK, Meriem
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie Physique Macromoléculaire [LCPM]
dc.contributor.authorFERJI, Khalid
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorCOMBET, Jérôme
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorSCHMUTZ, Marc
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierInstitut Charles Sadron [ICS]
dc.contributor.authorMARQUES, Carlos
dc.date.accessioned2020
dc.date.available2020
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19687
dc.description.abstractEnHealth concerns associated with the advent of nanotechnologies have risen sharply when it was found that particles of nanoscopic dimensions reach the cell lumina. Plasma and organelle lipid membranes, which are exposed to both the incoming and the engulfed nanoparticles, are the primary targets of possible disruptions. However, reported adhesion, invagination and embedment of nanoparticles (NPs) do not compromise the membrane integrity, precluding direct bilayer damage as a mechanism for toxicity. Here it is shown that a lipid membrane can be torn by small enough nanoparticles, thus unveiling mechanisms for how lipid membrane can be compromised by tearing from nanoparticles. Surprisingly, visualization by cryo transmission electron microscopy (cryo-TEM) of liposomes exposed to nanoparticles revealed also that liposomal laceration is prevented by particle abundance. Membrane destruction results thus from a subtle particle-membrane interplay that is here elucidated. This brings into a firmer molecular basis the theorized mechanisms of nanoparticle effects on lipid bilayers and paves the way for a better assessment of nanoparticle toxicity.
dc.description.sponsorshipCinétique de Translocation de Particules à travers de Bicouches Auto-Assemblées - ANR-12-BS08-0018
dc.language.isoen
dc.subject.enlipid membranes
dc.subject.ennanoparticles
dc.subject.ensilica particles
dc.subject.encryo-electron microscopy
dc.subject.ennano- toxicity
dc.title.enTear of Lipid Membranes by Nanoparticles
dc.typeDocument de travail - Pré-publication
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.identifier.arxiv2001.00525
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
hal.identifierhal-02568518
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02568518v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=ER-RAFIK,%20Meriem&FERJI,%20Khalid&COMBET,%20J%C3%A9r%C3%B4me&SANDRE,%20Olivier&LECOMMANDOUX,%20Sebastien&rft.genre=preprint


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