Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GEORGILIS, Evangelos | |
hal.structure.identifier | Eindhoven University of Technology [Eindhoven] [TU/e] | |
dc.contributor.author | ABDELGHANI, Mona | |
hal.structure.identifier | Eindhoven University of Technology [Eindhoven] [TU/e] | |
dc.contributor.author | PILLE, Jan | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | AYDINLIOGLU, Esra | |
hal.structure.identifier | Eindhoven University of Technology [Eindhoven] [TU/e] | |
dc.contributor.author | VAN HEST, Jan C.M. | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19670 | |
dc.description.abstractEn | Medicine formulations at the nanoscale, referred to as nanomedicines, have managed to overcome key challenges encountered during the development of new medical treatments and entered clinical practice, but considerable improvement in terms of local efficacy and reduced toxicity still need to be achieved. Currently, the fourth-generation of nanomedicines is being developed, employing biocompatible nanocarriers that are targeted, multifunctional, and stimuli-responsive. Proteins and polypeptides can fit the standards of an efficient nanovector because of their biodegradability, intrinsic bioactivity, chemical reactivity, stimuli-responsiveness, and ability to participate in complex supramolecular assemblies. These biomacromolecules can be obtained from natural resources, produced in heterologous hosts, or chemically synthesized, allowing for different designs to access suitable carriers for a variety of drugs. To enhance targeting or therapeutic functionality, additional chemical modifications can be applied. This review demonstrates the potential of polypeptide and protein materials for the design of drug delivery nanocarriers with a special focus on their preclinical evaluation in vitro and in vivo. | |
dc.description.sponsorship | Développement de polymersomes avec possibilité de suivi par imagerie et activation à distance pour la libération de composés d’intérêt thérapeutique dans des tissus profonds | |
dc.description.sponsorship | Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002 | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.subject.en | Polypeptides | |
dc.subject.en | Synthetic proteins | |
dc.subject.en | Nanomedecine | |
dc.subject.en | Drug delivery | |
dc.subject.en | Nanocarriers | |
dc.subject.en | Nanoparticles/administration & dosage | |
dc.title.en | Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.ijpharm.2020.119537 | |
dc.subject.hal | Chimie/Polymères | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | |
dc.subject.hal | Sciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux | |
dc.description.sponsorshipEurope | Nanomedicine: an integrative approach | |
bordeaux.journal | International Journal of Pharmaceutics | |
bordeaux.page | 119537 | |
bordeaux.volume | 586 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02863342 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02863342v1 | |
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