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Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action

hal.structure.identifierUnité Biogéochimie et Ecotoxicologie [BE]
dc.contributor.authorVIGNET, Caroline
hal.structure.identifierPhysiopathologie Animale et bioThérapie du muscle et du système nerveux [PAnTher]
dc.contributor.authorLARCHER, Thibaut
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDAVAIL, Blandine
hal.structure.identifierLaboratoire Ressources Halieutiques La Rochelle-L'Houmeau [ LRHLR]
dc.contributor.authorJOASSARD, Lucette
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLE MENACH, Karyn
IDREF: 256879966
hal.structure.identifierLaboratoire Ressources Halieutiques La Rochelle-L'Houmeau [ LRHLR]
dc.contributor.authorGUIONNET, Tiphaine
hal.structure.identifierLaboratoire Ressources Halieutiques La Rochelle-L'Houmeau [ LRHLR]
hal.structure.identifierUnité Biogéochimie et Ecotoxicologie [BE]
dc.contributor.authorLYPHOUT, Laura
hal.structure.identifierPhysiopathologie Animale et bioThérapie du muscle et du système nerveux [PAnTher]
dc.contributor.authorLEDEVIN, Mireille
hal.structure.identifierUnité Biogéochimie et Ecotoxicologie [BE]
dc.contributor.authorGOUBEAU, Manon
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
hal.structure.identifierLaboratoire Ressources Halieutiques La Rochelle-L'Houmeau [ LRHLR]
dc.contributor.authorBÉGOUT, Marie-Laure
hal.structure.identifierLaboratoire de Physiologie et Génomique des Poissons [LPGP]
hal.structure.identifierUnité Biogéochimie et Ecotoxicologie [BE]
hal.structure.identifierMARine Biodiversity Exploitation and Conservation [UMR MARBEC]
dc.contributor.authorCOUSIN, Xavier
dc.date.accessioned2024-04-04T12:31:19Z
dc.date.available2024-04-04T12:31:19Z
dc.date.issued2016-10-28
dc.identifier.issn2305-6304
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194930
dc.description.abstractEnPolycyclic aromatic hydrocarbons (PAHs) constitute a large family of organic pollutants emitted in the environment as complex mixtures, the compositions of which depend on origin. Among a wide range of physiological defects, PAHs are suspected to be involved in disruption of reproduction. In an aquatic environment, the trophic route is an important source of chronic exposure to PAHs. Here, we performed trophic exposure of zebrafish to three fractions of different origin, one pyrolytic and two petrogenic. Produced diets contained PAHs at environmental concentrations. Reproductive traits were analyzed at individual, tissue and molecular levels. Reproductive success and cumulative eggs number were disrupted after exposure to all three fractions, albeit to various extents depending on the fraction and concentrations. Histological analyses revealed ovary maturation defects after exposure to all three fractions as well as degeneration after exposure to a pyrolytic fraction. In testis, hypoplasia was observed after exposure to petrogenic fractions. Genes expression analysis in gonads has allowed us to establish common pathways such as endocrine disruption or differentiation/maturation defects. Taken altogether, these results indicate that PAHs can indeed disrupt fish reproduction and that different fractions trigger different pathways resulting in different effects.
dc.description.sponsorshipContamination et physiologie des poissons aux polluants - ANR-09-CESA-0002
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enmolecular mechanisms
dc.subject.engonad differentiation
dc.subject.enfertilization
dc.subject.enspawning success
dc.subject.enpolycyclic aromatic hydrocarbons
dc.subject.enzebrafish
dc.title.enFish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/toxics4040026
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie
dc.subject.halSciences de l'environnement/Biodiversité et Ecologie
dc.subject.halSciences du Vivant [q-bio]/Biologie de la reproduction
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Zoologie des vertébrés
bordeaux.journalToxicsen_US
bordeaux.page26
bordeaux.volume4
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue4
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01425791
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Toxics&rft.date=2016-10-28&rft.volume=4&rft.issue=4&rft.spage=26&rft.epage=26&rft.eissn=2305-6304&rft.issn=2305-6304&rft.au=VIGNET,%20Caroline&LARCHER,%20Thibaut&DAVAIL,%20Blandine&JOASSARD,%20Lucette&LE%20MENACH,%20Karyn&rft.genre=article


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