Spatial modelling of tumour drug resistance: the case of GIST liver metastases Mathematical Medicine and Biology Advance
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
dc.contributor.author | LEFEBVRE, Guillaume | |
hal.structure.identifier | CHU de Bordeaux Pellegrin [Bordeaux] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | CORNELIS, François | |
hal.structure.identifier | Centre for Biotechnology and Bioengineering [Santiago] [CeBiB] | |
hal.structure.identifier | Group of investigation in tumor angiogenesis [Concepción] [GIANT] | |
hal.structure.identifier | Group of applied mathematics [Concepción] [GMA] | |
dc.contributor.author | CUMSILLE, Patricio | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
dc.contributor.author | COLIN, Thierry | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
dc.contributor.author | POIGNARD, Clair | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
dc.contributor.author | SAUT, Olivier | |
dc.date.accessioned | 2024-04-04T03:13:28Z | |
dc.date.available | 2024-04-04T03:13:28Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1477-8599 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/193951 | |
dc.description.abstractEn | This work is devoted to modelling gastrointestinal stromal tumour metastases to the liver, their growth and resistance to therapies. More precisely, resistance to two standard treatments based on tyrosine kinase inhibitors (imatinib and sunitinib) is observed clinically. Using observations from medical images (CT scans), we build a spatial model consisting in a set of non-linear partial differential equations. After calibration of its parameters with clinical data, this model reproduces qualitatively and quantitatively the spatial tumour evolution of one specific patient. Important features of the growth such as the appearance of spatial heterogeneities and the therapeutical failures may be explained by our model. We then investigate numerically the possibility of optimizing the treatment in terms of progression-free survival time and minimum tumour size reachable by varying the dose of the first treatment. We find that according to our model, the progression-free survival time reaches a plateau with respect to this dose. We also demonstrate numerically that the spatial structure of the tumour may provide much more insights on the cancer cell activities than the standard RECIST criteria, which only consists in the measurement of the tumour diameter. Finally, we discuss on the non-predictivity of the model using only CT scans, in the sense that the early behaviour of the lesion is not sufficient to predict the response to the treatment. | |
dc.description.sponsorship | Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057 | |
dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003 | |
dc.language.iso | en | |
dc.publisher | Oxford University Press (OUP) | |
dc.subject.en | tumour growth modelling | |
dc.subject.en | partial differential equations | |
dc.subject.en | cancer | |
dc.subject.en | drug resistance | |
dc.subject.en | tumour heterogeneity | |
dc.title.en | Spatial modelling of tumour drug resistance: the case of GIST liver metastases Mathematical Medicine and Biology Advance | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1093/imammb/dqw002 | |
dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
bordeaux.journal | Mathematical Medicine and Biology | |
bordeaux.page | 1 - 26 | |
bordeaux.volume | 00 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01380292 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01380292v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Mathematical%20Medicine%20and%20Biology&rft.date=2016&rft.volume=00&rft.spage=1%20-%2026&rft.epage=1%20-%2026&rft.eissn=1477-8599&rft.issn=1477-8599&rft.au=LEFEBVRE,%20Guillaume&CORNELIS,%20Fran%C3%A7ois&CUMSILLE,%20Patricio&COLIN,%20Thierry&POIGNARD,%20Clair&rft.genre=article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |