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Sensitivity Analysis of Ventricular Activation and Electrocardiogram in Tailored Models of Heart-Failure Patients

hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorSÁNCHEZ, Carlos
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorD'AMBROSIO, Gabriele
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorMAFFESSANTI, Francesco
hal.structure.identifierDipartimento di Elettronica, Informazione e Bioingegneria [DEIB]
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorCAIANI, Enrico
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierMaastricht University [Maastricht]
dc.contributor.authorPRINZEN, Frits
hal.structure.identifierFaculty of Informatics [Lugano]
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorKRAUSE, Rolf
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorAURICCHIO, Angelo
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorPOTSE, Mark
dc.date.accessioned2024-04-04T03:09:31Z
dc.date.available2024-04-04T03:09:31Z
dc.date.created2017-05-22
dc.date.issued2018-03
dc.identifier.issn0140-0118
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193611
dc.description.abstractEnCardiac resynchronization therapy is not effective in a variable proportion of heart failure patients. An accurate knowledge of each patient's electroanatomical features could be helpful to determine the most appropriate treatment. The goal of this study was to analyze and quantify the sensitivity of left ventricular (LV) activation and the electrocardiogram (ECG) to changes in 39 parameters used to tune realistic anatomical-electrophysiological models of the heart. Electrical activity in the ventricles was simulated using a reaction-diffusion equation. To simulate cellular electrophysiology, the Ten Tusscher-Panfilov 2006 model was used. Intracardiac electrograms and 12-lead ECGs were computed by solving the bidomain equation. Parameters showing the highest sensitivity values were similar in the six patients studied. QRS complex and LV activation times were modulated by the sodium current, the cell surface-to-volume ratio in the LV, and tissue conductivities. The T-wavewas modulated by the calcium and rectifier-potassium currents, and the cell surface-to-volume ratio in both ventricles. We conclude that homogeneous changes in ionic currents entail similar effects in all ECG leads, whereas the effects of changes in tissue properties show larger inter-lead variability. The effects of parameter variations are highly consistent between patients and most of the model tuning could be performed with only ~10 parameters.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enPatient-specific model
dc.subject.enECG morphology
dc.subject.enSensitivity analysis
dc.subject.enComputer simulation
dc.subject.enLeft bundle branch block
dc.subject.enHeart failure
dc.subject.meshHeart Failure
dc.subject.meshCardiac electrophysiology
dc.subject.meshMathematical Computation
dc.title.enSensitivity Analysis of Ventricular Activation and Electrocardiogram in Tailored Models of Heart-Failure Patients
dc.typeArticle de revue
dc.identifier.doi10.1007/s11517-017-1696-9
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalMedical and Biological Engineering and Computing
bordeaux.page491-504
bordeaux.volume56
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01567886
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01567886v1
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