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MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery

hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorLORENZATO, Cyril
hal.structure.identifierMedisysResearch Lab [Medisys]
dc.contributor.authorCERNICANU, Alexandru
hal.structure.identifierNanobiotix
dc.contributor.authorMEYRE, Marie-Edith
hal.structure.identifierUMR CNRS 8179
dc.contributor.authorGERMAIN, Matthieu
hal.structure.identifierNanobiotix
dc.contributor.authorPOTTIER, Agnès
hal.structure.identifierNanobiotix
dc.contributor.authorLEVY, Laurent
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorBOS, Clemens
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorMOONEN, Chrit
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorSMIRNOV, Pierre
dc.date.accessioned2024-04-04T03:09:15Z
dc.date.available2024-04-04T03:09:15Z
dc.date.issued2013
dc.identifier.issn1555-4309
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193591
dc.description.abstractEnImproved drug delivery control during chemotherapy is a major concern to increase their therapeutic index. Drug accumulation in solid tumor can be visualized using MRI contrast agent such as iron oxide nanoparticles encapsulated in liposomes. Once accumulated in tumor, the combination of a thermosensitive composition with an external source of activation allows local release of drug. MRI guided-High intensity focused ultrasound (HIFU) represents a non invasive technique to generate local hyperthermia for drug release of thermosensitive magnetoliposomes (TSM). In this study we performed encapsulation of ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in thermosensitive liposomes to obtain TSM. Magnetic behavior of this MRI contrast agent was observed during TSM membrane permeabilization. For this, measurement of transverse and longitudinal relaxivities on MRI, and real time experiments were performed on TSM samples loaded with USPIO during heating using a water bath or HIFU. Results showed significant differences for MRI signal enhancement and relaxivities ratios before and after heating, which were absent for non-thermosensitive liposomes and free nanoparticles used as controls. Thus, incorporation of USPIO as MRI-contrast agents into thermosensitive liposomes should, besides TSM tumor accumulation, allows the visualization of TSM membrane permeabilization upon temperature elevation. In conclusion, HIFU under MR image guidance in combination with USPIO loaded thermosensitive liposomes as drug delivery system has the potential for a better control of drug delivery and to increase the therapeutic index of chemotherapy.
dc.language.isoen
dc.publisherWiley
dc.subject.enThermosensitive liposomes
dc.subject.enMRI
dc.subject.enLocal drug delivery
dc.subject.enUltrasound
dc.title.enMRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery
dc.typeArticle de revue
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
bordeaux.journalContrast Media and Molecular Imaging
bordeaux.page185-192
bordeaux.volume8
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01578206
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01578206v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Contrast%20Media%20and%20Molecular%20Imaging&rft.date=2013&rft.volume=8&rft.issue=2&rft.spage=185-192&rft.epage=185-192&rft.eissn=1555-4309&rft.issn=1555-4309&rft.au=LORENZATO,%20Cyril&CERNICANU,%20Alexandru&MEYRE,%20Marie-Edith&GERMAIN,%20Matthieu&POTTIER,%20Agn%C3%A8s&rft.genre=article


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