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Real-time Volumetric MRI Thermometry of Focused Ultrasound Ablation in vivo : A feasibility study in pig liver and kidney

hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorQUESSON, Bruno
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCHRISTOPHE, Laurent
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorMACLAIR, G.
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorMOUGENOT, Charles
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorRIES, Mario
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCARTERET, Thibaut
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorRULLIER, A.
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorMOONEN, Chrit
dc.date.accessioned2024-04-04T03:07:04Z
dc.date.available2024-04-04T03:07:04Z
dc.date.issued2011
dc.identifier.issn0952-3480
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193400
dc.description.abstractEnMR thermometry offers the possibility to precisely guide high-intensity focused ultrasound (HIFU) for the noninvasive treatment of kidney and liver tumours. The objectives of this study were to demonstrate therapy guidance by motion-compensated, rapid and volumetric MR temperature monitoring and to evaluate the feasibility of MR-guided HIFU ablation in these organs. Fourteen HIFU sonications were performed in the kidney and liver of five pigs under general anaesthesia using an MR-compatible Philips HIFU platform prototype. HIFU sonication power and duration were varied. Volumetric MR thermometry was performed continuously at 1.5 T using the proton resonance frequency shift method employing a multi-slice, single-shot, echo-planar imaging sequence with an update frequency of 2.5 Hz. Motion-related suceptibility artefacts were compensated for using multi-baseline reference images acquired prior to sonication. At the end of the experiment, the animals were sacrificed for macroscopic and microscopic examinations of the kidney, liver and skin. The standard deviation of the temperature measured prior to heating in the sonicated area was approximately 1-C in kidney and liver, and 2.5-C near the skin. The maximum temperature rise was 30-C for a sonication of 1.2 MHz in the liver over 15 s at 300 W. The thermal dose reached the lethal threshold (240CEM 43) in two of six cases in the kidney and four of eight cases in the liver, but remained below this value in skin regions in the beam path. These findings were in agreement with histological analysis. Volumetric thermometry allows real-time monitoring of the temperature at the target location in liver and kidney, as well as in surrounding tissues. Thermal ablation was more difficult to achieve in renal than in hepatic tissue even using higher acoustic energy, probably because of a more efficient heat evacuation in the kidney by perfusion.
dc.language.isoen
dc.publisherWiley
dc.subject.enMRI thermometry
dc.subject.enhigh-intensity focused ultrasound (HIFU)
dc.subject.enliver
dc.subject.enkidney
dc.subject.enablation
dc.title.enReal-time Volumetric MRI Thermometry of Focused Ultrasound Ablation in vivo : A feasibility study in pig liver and kidney
dc.typeArticle de revue
dc.identifier.doi10.1002/nbm.1563
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
dc.subject.halInformatique [cs]/Traitement du signal et de l'image
bordeaux.journalNMR in Biomedicine
bordeaux.page145-153
bordeaux.volume24
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01064550
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01064550v1
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