A continuum mechanics model of enzyme-based tissue degradation in cancer therapies
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| dc.contributor.author | DEVILLE, Manon | |
| hal.structure.identifier | National Research Council of Italy | Consiglio Nazionale delle Ricerche [CNR] | |
| dc.contributor.author | NATALINI, Roberto | |
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
| dc.contributor.author | POIGNARD, Clair | |
| dc.date | 2018 | |
| dc.date.accessioned | 2024-04-04T03:04:59Z | |
| dc.date.available | 2024-04-04T03:04:59Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 0092-8240 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/193205 | |
| dc.description.abstractEn | We propose a mathematical model to describe enzyme-based tissue degradation in cancer therapies. The proposed model combines the poroelastic theory of mixtures with the transport of enzymes or drugs in the extracellular space. The effect of the matrix degrading enzymes on the tissue composition and its mechanical response are accounted for. Numerical simulations in 1D, 2D and ax-isymmetric (3D) configurations show how an injection of matrix degrading enzymes alters the porosity of a biological tissue. We eventually exhibit numerically the main consequences of a matrix degrading enzyme pretreatment in the framework of chemotherapy: the removal of the diffusive hindrance to the penetration of therapeutic molecules in tumors and the reduction of interstitial fluid pressure which improves transcapillary transport. Both effects are consistent with previous biological observations. | |
| dc.language.iso | en | |
| dc.publisher | Springer Verlag | |
| dc.subject.en | Drug distribution in tissue | |
| dc.subject.en | Mathematical biology | |
| dc.subject.en | ECM degradation | |
| dc.subject.en | Interstitial fluid pressure | |
| dc.subject.en | Poroelasticity | |
| dc.title.en | A continuum mechanics model of enzyme-based tissue degradation in cancer therapies | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1007/s11538-018-0515-2 | |
| dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
| bordeaux.journal | Bulletin of Mathematical Biology | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01889575 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01889575v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bulletin%20of%20Mathematical%20Biology&rft.date=2018&rft.eissn=0092-8240&rft.issn=0092-8240&rft.au=DEVILLE,%20Manon&NATALINI,%20Roberto&POIGNARD,%20Clair&rft.genre=article |
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