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A left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study

hal.structure.identifierDepartment of Physiology [Maastricht]
dc.contributor.authorNGUYÊN, Uyên Châu
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPOTSE, Mark
hal.structure.identifierRadboud University Medical Center [Nijmegen]
dc.contributor.authorVERNOOY, Kevin
hal.structure.identifierCardiovascular Research Institute Maastricht [CARIM]
dc.contributor.authorMAFI-RAD, Masih
hal.structure.identifierCardiovascular Research Institute Maastricht [CARIM]
dc.contributor.authorHEIJMAN, Jordi
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorCAPUTO, Maria
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorCONTE, Giulio
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorREGOLI, François
hal.structure.identifierInstitute of Computational Science [ICS]
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorKRAUSE, Rolf
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorMOCCETTI, Tiziano
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorAURICCHIO, Angelo
hal.structure.identifierDepartment of Physiology [Maastricht]
dc.contributor.authorPRINZEN, Frits
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorMAFFESSANTI, Francesco
dc.date.accessioned2024-04-04T03:03:59Z
dc.date.available2024-04-04T03:03:59Z
dc.date.issued2018-11-01
dc.identifier.issn1099-5129
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193113
dc.description.abstractEnAims The aim of this study was to investigate the influence of the activation sequence on voltage amplitudes by evaluating regional voltage differences during a left bundle branch block (LBBB) activation sequence vs. a normal synchronous activation sequence and by evaluating pacing-induced voltage differences. Twenty-one patients and three computer models without scar were studied. Regional voltage amplitudes were evaluated in nine LBBB patients who underwent endocardial electro-anatomic mapping (EAM). Pacing-induced voltage differences were evaluated in 12 patients who underwent epicardial EAM during intrinsic rhythm and right ven-tricular (RV) pacing. Three computer models customized for LBBB patients were created. Changes in voltage amplitudes after an LBBB (intrinsic), a normal synchronous, an RV pacing, and a left ventricular pacing activation sequence were assessed in the computer models. Unipolar voltage amplitudes in patients were approximately ~4.5 mV (4.4-4.7 mV, ~33%) lower in the septum when compared with other segments. A normal synchronous activation sequence in the computer models normalized voltage amplitudes in the septum. Pacing-induced differences were larger in electrograms with higher voltage amplitudes during intrinsic rhythm and furthermore larger and more variable at the epicardium [mean absolute difference: 3.6-6.2 mV, 40-53% of intrinsic value; interquartile range (IQR) differences: 53-63% of intrinsic value] compared to the endocardium (mean absolute difference: 3.3-3.8 mV, 28
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.enIntra-cardiac electrogram
dc.subject.enVoltage amplitude
dc.subject.enHeart failure
dc.subject.enLeft bundle branch block
dc.subject.enActivation sequence
dc.subject.enComputer models
dc.subject.enAnisotropy
dc.title.enA left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study
dc.typeArticle de revue
dc.identifier.doi10.1093/europace/euy233
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalEP-Europace
bordeaux.pageiii77 - iii86
bordeaux.volume20
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issuesuppl-3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01933819
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01933819v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EP-Europace&rft.date=2018-11-01&rft.volume=20&rft.issue=suppl-3&rft.spage=iii77%20-%20iii86&rft.epage=iii77%20-%20iii86&rft.eissn=1099-5129&rft.issn=1099-5129&rft.au=NGUY%C3%8AN,%20Uy%C3%AAn%20Ch%C3%A2u&POTSE,%20Mark&VERNOOY,%20Kevin&MAFI-RAD,%20Masih&HEIJMAN,%20Jordi&rft.genre=article


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