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Thermodynamical Fluxes for the Modeling of Cardiac Mitochondrial Calcium Handling

hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorTARRAF, Bachar
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorLEGUÈBE, Michael
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDIOLEZ, Philippe
dc.date.accessioned2024-04-04T02:59:42Z
dc.date.available2024-04-04T02:59:42Z
dc.date.conference2019-09-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192760
dc.description.abstractEnIt is known that mitochondria play a crucial role in the handling of calcium by cardiac cells during the excitation-contraction cycle. However, the precise characterization of this role is still under debate. With this intent, a collection of mathematical models have been developed, but they generally show a level of complexity that is not compatible with inverse problem techniques required for calibration with experimental data. Their large number of equations and parameters can also lead to transcription mistakes that can be found in the literature. In this paper we apply a similar methodology as Bertram et al.in [1] to propose a simple model that is derived from the base equations that constitute the origin of most mitochondrial models [2]. Our model describes the main features of the mitochon-drial activity with 6 equations and ∼30 parameters, which we will eventually reduce in a forthcoming sensitivity analysis .
dc.description.sponsorshipElectrophysiologie de la Mitochondrie Cardiaque - ANR-17-CE11-0041
dc.language.isoen
dc.title.enThermodynamical Fluxes for the Modeling of Cardiac Mitochondrial Calcium Handling
dc.typeCommunication dans un congrès
dc.subject.halMathématiques [math]
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleCinC 2019 - Computing In Cardiology 2019
bordeaux.countrySG
bordeaux.conference.citySingapour
bordeaux.peerReviewedoui
hal.identifierhal-02299233
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2019-09-11
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02299233v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=TARRAF,%20Bachar&LEGU%C3%88BE,%20Michael&COUDI%C3%88RE,%20Yves&DIOLEZ,%20Philippe&rft.genre=unknown


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