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Evaluating the benefit of PBS vs. VMAT dose distributions in terms of dosimetric sparing and robustness against inter-fraction anatomical changes for pediatric abdominal tumors

hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorGUERREIRO, Filipa
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorZACHIU, Cornel
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorSERAVALLI, Enrica
hal.structure.identifierUniversity Medical Center Groningen [Groningen] [UMCG]
dc.contributor.authorCASSIA ORABONI, Ribeiro
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorJANSSENS, Geert
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorRIES, Mario
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity Medical Center Groningen [Groningen] [UMCG]
dc.contributor.authorMADURO, John
hal.structure.identifierUniversity Medical Center Groningen [Groningen] [UMCG]
dc.contributor.authorBROUWER, Charlotte
hal.structure.identifierUniversity Medical Center Groningen [Groningen] [UMCG]
dc.contributor.authorKOREVAAR, Erik
hal.structure.identifierUniversity Medical Center Groningen [Groningen] [UMCG]
dc.contributor.authorKNOPF, Antje
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorRAAYMAKERS, Bas
dc.date.accessioned2024-04-04T02:58:42Z
dc.date.available2024-04-04T02:58:42Z
dc.date.issued2019-09-01
dc.identifier.issn0167-8140
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192679
dc.description.abstractEnBACKGROUND AND PURPOSE:To evaluate the dosimetric sparing and robustness against inter-fraction anatomical changes between photon and proton dose distributions for children with abdominal tumors.MATERIAL AND METHODS:Volumetric modulated arc therapy (VMAT) and intensity-modulated pencil beam scanning (PBS) proton dose distributions were calculated for 20 abdominal pediatric cases (average 3, range 1-8 years). VMAT plans were based on a full-arc while PBS plans on 2-3 posterior-oblique irradiation fields. Plans were robustly optimized on a patient-specific internal target volume (ITV) using a uniform 5 mm set-up uncertainty. Additionally, for the PBS plans a ± 3% proton range uncertainty was accounted for. Fractional dose re-calculations were performed using the planning computed tomography (CT) deformably registered to the daily cone-beam CT (CBCT) images. Fractional doses were accumulated rigidly. Planned and CBCT accumulated VMAT and PBS dose distributions were compared using dose-volume histogram (DVH) parameters.RESULTS:Significant better sparing of the organs at risk with a maximum reduction in the mean dose of 40% was achieved with PBS. Mean ITV DVH parameters differences between planned and CBCT accumulated dose distributions were smaller than 0.5% for both VMAT and PBS. However, the ITV coverage (V95% > 99%) was not reached for one patient for the accumulated VMAT dose distribution.CONCLUSIONS:For pediatric patients with abdominal tumors, improved dosimetric sparing was obtained with PBS compared to VMAT. In addition, PBS delivered by posterior-oblique irradiation fields demonstrated to be robust against anatomical inter-fraction changes. Compared to PBS, daily anatomical changes proved to affect the target coverage of VMAT dose distributions to a higher extent.
dc.language.isoen
dc.publisherElsevier
dc.subject.enVMAT
dc.subject.enRe-planning
dc.subject.enInter-fraction uncertainties
dc.subject.enChildren abdominal tumors
dc.subject.enRobust pencil beam scanning
dc.subject.enPediatric IGRT
dc.subject.enProton therapy
dc.title.enEvaluating the benefit of PBS vs. VMAT dose distributions in terms of dosimetric sparing and robustness against inter-fraction anatomical changes for pediatric abdominal tumors
dc.typeArticle de revue
dc.identifier.doi10.1016/j.radonc.2019.06.025
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
bordeaux.journalRadiotherapy & Oncology
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02387725
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02387725v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Radiotherapy%20&%20Oncology&rft.date=2019-09-01&rft.eissn=0167-8140&rft.issn=0167-8140&rft.au=GUERREIRO,%20Filipa&ZACHIU,%20Cornel&SERAVALLI,%20Enrica&CASSIA%20ORABONI,%20Ribeiro&JANSSENS,%20Geert&rft.genre=article


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