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hal.structure.identifierCHU Bordeaux
dc.contributor.authorBRONNIMANN, Charlotte
hal.structure.identifierCHU Bordeaux
dc.contributor.authorHUCHET, Aymeri
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBENECH-FAURE, Julie
hal.structure.identifierCHU Bordeaux
dc.contributor.authorDUTRIAUX, Caroline
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorSAUT, Olivier
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBLAIS, Eivind
hal.structure.identifierCHU Bordeaux
dc.contributor.authorMOLLIER, Olivier
hal.structure.identifierCHU Bordeaux
dc.contributor.authorTROUETTE, Renaud
hal.structure.identifierCHU Bordeaux
hal.structure.identifierBiothérapies des maladies génétiques et cancers
dc.contributor.authorVENDRELY, Véronique
dc.date.accessioned2024-04-04T02:58:24Z
dc.date.available2024-04-04T02:58:24Z
dc.date.issued2019-10-01
dc.identifier.issn2054-2577
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192656
dc.description.abstractEnAbstractBackgroundAdvances in intracranial stereotactic radiosurgery (SRS) have led to dramatically reduced planning target volume (PTV) margins. However, tumor growth between planning and treatment may lead to treatment failure. Our purpose was to assess the kinetics of tumor growth before SRS for brain metastases.MethodsThis retrospective, monocentric study included all consecutive patients (pts) treated for brain metastases secondary to melanoma (ML) and non-small cell lung cancer (NSCLC) between June 2015 and May 2016. All pts underwent diagnostic brain imaging and a radiosurgery planning MRI, during which gross tumor volume (GTV) was delineated. Linear and exponential models were used to extrapolate a theoretical GTV at first day of treatment, and theoretical time to outgrow the PTV margins.ResultsTwenty-three ML and 31 NSCLC brain metastases (42 pts, 84 brain imaging scans) were analyzed. Comparison of GTV at diagnosis and planning showed increased tumor volume for 20 ML pts (96%) and 22 NSCLC pts (71%). The shortest time to outgrow a 1 mm margin was 6 days and 3 days for ML and 14 and 8 days for NSCLC with linear and exponential models, respectively.ConclusionsPhysicians should bear in mind the interval between SRS planning and treatment. A mathematical model could screen rapidly progressing tumors.
dc.language.isoen
dc.publisherOxford University Press
dc.subject.enBrain metastases
dc.subject.enStereotactic radiotherapy
dc.subject.enMargins
dc.subject.enInterval
dc.title.enInterval between planning and frameless stereotactic radiotherapy for brain metastases: are our margins still accurate?
dc.typeArticle de revue
dc.identifier.doi10.1093/nop/npz048
dc.subject.halMathématiques [math]/Equations aux dérivées partielles [math.AP]
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halInformatique [cs]/Modélisation et simulation
bordeaux.journalNeuro-Oncology Practice
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02406540
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02406540v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuro-Oncology%20Practice&rft.date=2019-10-01&rft.eissn=2054-2577&rft.issn=2054-2577&rft.au=BRONNIMANN,%20Charlotte&HUCHET,%20Aymeri&BENECH-FAURE,%20Julie&DUTRIAUX,%20Caroline&SAUT,%20Olivier&rft.genre=article


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