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Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

hal.structure.identifierIHU-LIRYC
dc.contributor.authorHAÏSSAGUERRE, Michel
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHOCINI, Mélèze
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCHENITI, Ghassen
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierIHU-LIRYC
dc.contributor.authorSACHER, Fréderic
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPUYO, Stéphane
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorCOCHET, Hubert
hal.structure.identifierIHU-LIRYC
dc.contributor.authorTAKIGAWA, Masateru
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDENIS, Arnaud
hal.structure.identifierIHU-LIRYC
dc.contributor.authorMARTIN, Ruairidh
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierHôpital Haut-Lévêque [CHU Bordeaux]
dc.contributor.authorBORDACHAR, Pierre
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorRITTER, Philippe
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPLOUX, Sylvain
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierIHU-LIRYC
dc.contributor.authorKLOTZ, Nicolas
hal.structure.identifierIHU-LIRYC
dc.contributor.authorMASSOULLIÉ, Grégoire
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPILLOIS, Xavier
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDALLET, Corentin
hal.structure.identifierITX - unité de recherche de l'institut du thorax [ITX]
dc.contributor.authorSCHOTT, Jean-Jacques
hal.structure.identifierITX - unité de recherche de l'institut du thorax [ITX]
dc.contributor.authorLE SCOUARNEC, Solena
hal.structure.identifierMayo Clinic
dc.contributor.authorACKERMAN, Michael
hal.structure.identifierMayo Clinic
dc.contributor.authorTESTER, David
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPIOT, Olivier
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierPhysiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
dc.contributor.authorPASQUIÉ, Jean Luc
hal.structure.identifierLaboratoire Traitement du Signal et de l'Image [LTSI]
dc.contributor.authorLECLERC, Christophe
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorHERMIDA, Jean-Sylvain
hal.structure.identifierUnité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
dc.contributor.authorGANDJBAKHCH, Estelle
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorMAURY, Philippe
hal.structure.identifierIHU-LIRYC
dc.contributor.authorLABROUSSE, Louis
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCORONEL, Ruben
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorJAÏS, Pierre
hal.structure.identifierBibliothèque interuniversitaire de santé [BIUS]
dc.contributor.authorBENOIST, David
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorVIGMOND, Edward J.
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierIHU-LIRYC
dc.contributor.authorWALTON, Richard D.
hal.structure.identifierWhite Memorial Medical Center
dc.contributor.authorNADEMANEE, Koonlawee
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBERNUS, Olivier
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUBOIS, Rémi
dc.date.accessioned2024-04-04T02:54:56Z
dc.date.available2024-04-04T02:54:56Z
dc.date.issued2018-07-12
dc.identifier.issn1941-3149
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192320
dc.description.abstractEnBackground - Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. Methods - We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm. Established electrogram criteria were used to identify the presence of structural alterations. Results - VF occurred spontaneously in 3 patients and was induced in 16, whereas VF was noninducible in 5. VF mapping demonstrated reentrant and focal activities (87% versus 13%, respectively) in all. The activities were dominant in one ventricle in 9 patients, whereas they had biventricular distribution in others. During sinus rhythm areas of abnormal electrograms were identified in 15/24 patients (62.5%) revealing localized structural alterations: in the right ventricle in 11, the left ventricle in 1, and both in 3. They covered a limited surface (13±6 cm) representing 5±3% of the total surface and were recorded predominantly on the epicardium. Seventy-six percent of these areas were colocated with VF drivers (<0.001). In the 9 patients without structural alteration, we observed a high incidence of Purkinje triggers (7/9 versus 4/15, =0.033). Catheter ablation resulted in arrhythmia-free outcome in 15/18 patients at 17±11 months follow-up. Conclusions - This study shows that localized structural alterations underlie a significant subset of previously unexplained sudden cardiac death. In the other subset, Purkinje electrical pathology seems as a dominant mechanism.
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.subject.enEpicardial mapping
dc.subject.enIncidence
dc.subject.enEndocardium
dc.subject.enCatheter ablation
dc.subject.enVentricular fibrillation
dc.subject.enSudden cardiac death
dc.title.enLocalized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death
dc.typeArticle de revue
dc.identifier.doi10.1161/CIRCEP.117.006120
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalCirculation. Arrhythmia and electrophysiology
bordeaux.pagee006120
bordeaux.volume11
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue7
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01839275
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01839275v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Circulation.%20Arrhythmia%20and%20electrophysiology&amp;rft.date=2018-07-12&amp;rft.volume=11&amp;rft.issue=7&amp;rft.spage=e006120&amp;rft.epage=e006120&amp;rft.eissn=1941-3149&amp;rft.issn=1941-3149&amp;rft.au=HA%C3%8FSSAGUERRE,%20Michel&amp;HOCINI,%20M%C3%A9l%C3%A8ze&amp;CHENITI,%20Ghassen&amp;DUCHATEAU,%20Josselin&amp;SACHER,%20Fr%C3%A9deric&amp;rft.genre=article


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