Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death
PASQUIÉ, Jean Luc
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
GANDJBAKHCH, Estelle
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
POTSE, Mark
IHU-LIRYC
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
< Reduce
IHU-LIRYC
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Language
en
Article de revue
This item was published in
Circulation. Arrhythmia and electrophysiology. 2018-07-12, vol. 11, n° 7, p. e006120
Lippincott Williams & Wilkins
English Abstract
Background - Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. Methods - We evaluated ...Read more >
Background - Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. Methods - We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm. Established electrogram criteria were used to identify the presence of structural alterations. Results - VF occurred spontaneously in 3 patients and was induced in 16, whereas VF was noninducible in 5. VF mapping demonstrated reentrant and focal activities (87% versus 13%, respectively) in all. The activities were dominant in one ventricle in 9 patients, whereas they had biventricular distribution in others. During sinus rhythm areas of abnormal electrograms were identified in 15/24 patients (62.5%) revealing localized structural alterations: in the right ventricle in 11, the left ventricle in 1, and both in 3. They covered a limited surface (13±6 cm) representing 5±3% of the total surface and were recorded predominantly on the epicardium. Seventy-six percent of these areas were colocated with VF drivers (<0.001). In the 9 patients without structural alteration, we observed a high incidence of Purkinje triggers (7/9 versus 4/15, =0.033). Catheter ablation resulted in arrhythmia-free outcome in 15/18 patients at 17±11 months follow-up. Conclusions - This study shows that localized structural alterations underlie a significant subset of previously unexplained sudden cardiac death. In the other subset, Purkinje electrical pathology seems as a dominant mechanism.Read less <
English Keywords
Epicardial mapping
Incidence
Endocardium
Catheter ablation
Ventricular fibrillation
Sudden cardiac death
Origin
Hal imported