Computational assessment of the functional role of sinoatrial node exit pathways in the human heart
| hal.structure.identifier | University of Manchester [Manchester] | |
| dc.contributor.author | KHARCHE, Sanjay | |
| hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
| dc.contributor.author | VIGMOND, Edward | |
| hal.structure.identifier | Washington State University [WSU] | |
| dc.contributor.author | EFIMOV, Igor | |
| hal.structure.identifier | University of Manchester [Manchester] | |
| dc.contributor.author | DOBRZYNSKI, Halina | |
| dc.date.accessioned | 2024-04-04T02:51:24Z | |
| dc.date.available | 2024-04-04T02:51:24Z | |
| dc.date.issued | 2017-09-05 | |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/191985 | |
| dc.description.abstractEn | The human right atrium and sinoatrial node (SAN) anatomy is complex. Optical mapping experiments suggest that the SAN is functionally insulated from atrial tissue except at discrete SAN-atrial electrical junctions called SAN exit pathways, SEPs. Additionally, histological imaging suggests the presence of a secondary pacemaker close to the SAN. We hypothesise that a) an insulating border-SEP anatomical configuration is related to SAN arrhythmia; and b) a secondary pacemaker, the paranodal area, is an alternate pacemaker but accentuates tachycardia. A 3D electro-anatomical computational model was used to test these hypotheses. | |
| dc.language.iso | en | |
| dc.publisher | Public Library of Science | |
| dc.title.en | Computational assessment of the functional role of sinoatrial node exit pathways in the human heart | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1371/journal.pone.0183727 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire | |
| bordeaux.journal | PLoS ONE | |
| bordeaux.page | e0183727 | |
| bordeaux.volume | 12 | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.issue | 9 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02885662 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02885662v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2017-09-05&rft.volume=12&rft.issue=9&rft.spage=e0183727&rft.epage=e0183727&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=KHARCHE,%20Sanjay&VIGMOND,%20Edward&EFIMOV,%20Igor&DOBRZYNSKI,%20Halina&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||