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hal.structure.identifierUniversity of Manchester [Manchester]
dc.contributor.authorKHARCHE, Sanjay
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierWashington State University [WSU]
dc.contributor.authorEFIMOV, Igor
hal.structure.identifierUniversity of Manchester [Manchester]
dc.contributor.authorDOBRZYNSKI, Halina
dc.date.accessioned2024-04-04T02:51:24Z
dc.date.available2024-04-04T02:51:24Z
dc.date.issued2017-09-05
dc.identifier.issn1932-6203
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191985
dc.description.abstractEnThe human right atrium and sinoatrial node (SAN) anatomy is complex. Optical mapping experiments suggest that the SAN is functionally insulated from atrial tissue except at discrete SAN-atrial electrical junctions called SAN exit pathways, SEPs. Additionally, histological imaging suggests the presence of a secondary pacemaker close to the SAN. We hypothesise that a) an insulating border-SEP anatomical configuration is related to SAN arrhythmia; and b) a secondary pacemaker, the paranodal area, is an alternate pacemaker but accentuates tachycardia. A 3D electro-anatomical computational model was used to test these hypotheses.
dc.language.isoen
dc.publisherPublic Library of Science
dc.title.enComputational assessment of the functional role of sinoatrial node exit pathways in the human heart
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pone.0183727
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalPLoS ONE
bordeaux.pagee0183727
bordeaux.volume12
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02885662
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02885662v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2017-09-05&rft.volume=12&rft.issue=9&rft.spage=e0183727&rft.epage=e0183727&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=KHARCHE,%20Sanjay&VIGMOND,%20Edward&EFIMOV,%20Igor&DOBRZYNSKI,%20Halina&rft.genre=article


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