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hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierIHU-LIRYC
dc.contributor.authorSTUYVERS, Bruno
dc.date.accessioned2024-04-04T02:51:08Z
dc.date.available2024-04-04T02:51:08Z
dc.date.issued2016-01
dc.identifier.issn0079-6107
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191970
dc.description.abstractEnThe His-Purkinje System (HPS) is responsible for the rapid electric conduction in the ventricles. It relays electrical impulses from the atrioventricular node to the muscle cells and, thus, coordinates the contraction of ventricles in order to ensure proper cardiac pump function. The HPS has been implicated in the genesis of ventricular tachycardia and fibrillation as a source of ectopic beats, as well as forming distinct portions of reentry circuitry. Despite its importance, it remains much less well characterized, structurally and functionally, than the myocardium. Notably, important differences exist with regard to cell structure and electrophysiology, including ion channels, intracellular calcium handling, and gap junctions. Very few computational models address the HPS, and the majority of organ level modeling studies omit it. This review will provide an overview of our current knowledge of structure and function (including electrophysiology) of the HPS. We will review the most recent advances in modeling of the system from the single cell to the organ level, with considerations for relevant interspecies distinctions.
dc.language.isoen
dc.publisherElsevier
dc.subject.enComputer modeling
dc.subject.enElectrophysiology
dc.subject.enHis-Purkinje system
dc.subject.enPurkinje fiber
dc.title.enModeling our understanding of the His-Purkinje system
dc.typeArticle de revue
dc.identifier.doi10.1016/j.pbiomolbio.2015.12.013
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalProgress in Biophysics and Molecular Biology
bordeaux.page179-188
bordeaux.volume120
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1-3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02886259
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02886259v1
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