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Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load

dc.contributor.authorCAMPOS, Fernando
hal.structure.identifierCalifornia State University [Northridge] [CSUN]
dc.contributor.authorSHIFERAW, Yohannes
dc.contributor.authorPRASSL, Anton
hal.structure.identifierJohns Hopkins University [JHU]
dc.contributor.authorBOYLE, Patrick
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierEuropean Space Research and Technology Centre [ESTEC]
dc.contributor.authorPLANK, Gernot
dc.date.accessioned2024-04-04T02:51:06Z
dc.date.available2024-04-04T02:51:06Z
dc.date.issued2015-07-01
dc.identifier.issn0008-6363
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191967
dc.description.abstractEnPremature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the conditions under which delayed afterdepolarizations resulting from stochastic subcellular SCR events can overcome electrotonic source-sink mismatch, leading to PVC initiation.
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.enDelayed afterdepolarization
dc.subject.enComputer-based model
dc.subject.enTriggered activity
dc.subject.enPurkinje system
dc.subject.enArrhythmia
dc.title.enStochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load
dc.typeArticle de revue
dc.identifier.doi10.1093/cvr/cvv149
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysique
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalCardiovascular Research
bordeaux.page175-183
bordeaux.volume107
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02886267
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02886267v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cardiovascular%20Research&rft.date=2015-07-01&rft.volume=107&rft.issue=1&rft.spage=175-183&rft.epage=175-183&rft.eissn=0008-6363&rft.issn=0008-6363&rft.au=CAMPOS,%20Fernando&SHIFERAW,%20Yohannes&PRASSL,%20Anton&BOYLE,%20Patrick&VIGMOND,%20Edward&rft.genre=article


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