Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load
Langue
en
Article de revue
Ce document a été publié dans
Cardiovascular Research. 2015-07-01, vol. 107, n° 1, p. 175-183
Oxford University Press (OUP)
Résumé en anglais
Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains ...Lire la suite >
Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the conditions under which delayed afterdepolarizations resulting from stochastic subcellular SCR events can overcome electrotonic source-sink mismatch, leading to PVC initiation.< Réduire
Mots clés en anglais
Delayed afterdepolarization
Computer-based model
Triggered activity
Purkinje system
Arrhythmia
Origine
Importé de halUnités de recherche